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Cacna2d3 Gene Detail
Summary
  • Symbol
    Cacna2d3
  • Name
    calcium channel, voltage-dependent, alpha2/delta subunit 3
  • Synonyms
    alpha 2 delta-3, alpha2delta3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338890
    NCBI Gene: 12294
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:28626900-29443821 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 16.80 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    22162 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338890
 protein coding gene Chr14:28626900-29444732 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021096
 protein coding gene Chr14:21968461-22818352 (-)
A/J MGP_AJ_G0021044
 protein coding gene Chr14:21145717-21957684 (-)
AKR/J MGP_AKRJ_G0021021
 protein coding gene Chr14:22210147-23033446 (-)
BALB/cJ MGP_BALBcJ_G0021048
 protein coding gene Chr14:21229746-22050044 (-)
C3H/HeJ MGP_C3HHeJ_G0020831
 protein coding gene Chr14:22064667-22895839 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021480
 protein coding gene Chr14:22863990-23728990 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019043
 protein coding gene Chr14:21229023-22039145 (-)
CAST/EiJ MGP_CASTEiJ_G0020356
 protein coding gene Chr14:21755407-22620298 (-)
CBA/J MGP_CBAJ_G0020798
 protein coding gene Chr14:23746991-24634263 (-)
DBA/2J MGP_DBA2J_G0020920
 protein coding gene Chr14:21189261-22003694 (-)
FVB/NJ MGP_FVBNJ_G0020904
 protein coding gene Chr14:21138163-21949948 (-)
LP/J MGP_LPJ_G0020989
 protein coding gene Chr14:22296908-23139340 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020930
 protein coding gene Chr14:23078106-23948231 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021513
 protein coding gene Chr14:21968129-22801029 (-)
PWK/PhJ MGP_PWKPhJ_G0020104
 protein coding gene Chr14:20611983-21424299 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019928
 protein coding gene Chr14:21504964-22350992 (-)
WSB/EiJ MGP_WSBEiJ_G0020411
 protein coding gene Chr14:22026007-22860770 (-)



Homology
more
  • Human Ortholog
    CACNA2D3, calcium voltage-gated channel auxiliary subunit alpha2delta 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CACNA2D3, calcium voltage-gated channel auxiliary subunit alpha2delta 3
  • Synonyms
    HSA272268
  • Links
    NCBI Gene ID: 55799
    neXtProt AC: NX_Q8IZS8
    UniProt: Q8IZS8

  • Chr Location
    3p21.1-p14.3; chr3:54122552-55074557 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a decreased startle reflex and occasional animals show increased aggression and hyperactivity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1011
  • Tissues
    88
  • cDNA Data
    15
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      54
    • RefSeq
      11
    • UniProt
      6
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021991 Ensembl Gene Model | MGI Sequence Detail 816922 C57BL/6J ±  kb
    transcript ENSMUST00000022567 Ensembl | MGI Sequence Detail 3695 Not Applicable  
    polypeptide ENSMUSP00000022567 Ensembl | MGI Sequence Detail 1091 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000004944 voltage-dependent calcium channel subunit alpha-2/delta-3
      (term hierarchy)
    • InterPro Domains
      IPR013680 Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region
      IPR051173 Voltage-dependent calcium channel subunit alpha-2/delta
      IPR036465 von Willebrand factor A-like domain superfamily
      IPR002035 von Willebrand factor, type A
      IPR013608 VWA N-terminal
    • GlyGen
      Q9Z1L5 7 sites, 6 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 15
      Primer pair 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 16
      Gene Ontology 4
      Phenotypes 23
    • Earliest
      J:52012 Klugbauer N, et al., Molecular diversity of the calcium channel alpha2delta subunit. J Neurosci. 1999 Jan 15;19(2):684-91
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory