Padi2 MGI Mouse Gene Detail - MGI:1338892 - peptidyl arginine deiminase, type II

Symbol

Padi2
Name

peptidyl arginine deiminase, type II
Synonyms

mKIAA0994, PAD type II, Pdi, Pdi2

Feature Type

protein coding gene
IDs

MGI:1338892
NCBI Gene: 18600
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr4:140633685-140679897 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 73.01 cM, cytoband E1
Mapping Data

6 experiments

SNPs within 2kb

614 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338892	protein coding gene	Chr4:140633655-140679897 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029032	protein coding gene	Chr4:143893200-143941281 (+)
A/J	MGP_AJ_G0028991	protein coding gene	Chr4:137656981-137711467 (+)
AKR/J	MGP_AKRJ_G0028943	protein coding gene	Chr4:141637837-141681882 (+)
BALB/cJ	MGP_BALBcJ_G0029015	protein coding gene	Chr4:138358033-138399260 (+)
C3H/HeJ	MGP_C3HHeJ_G0028729	protein coding gene	Chr4:142020904-142066397 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029456	protein coding gene	Chr4:148947425-148994868 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026727	protein coding gene	Chr4:130585777-130627244 (+)
CAST/EiJ	MGP_CASTEiJ_G0028161	protein coding gene	Chr4:140267957-140313189 (+)
CBA/J	MGP_CBAJ_G0028693	protein coding gene	Chr4:153220414-153277603 (+)
DBA/2J	MGP_DBA2J_G0028843	protein coding gene	Chr4:138063304-138105104 (+)
FVB/NJ	MGP_FVBNJ_G0028810	protein coding gene	Chr4:137160103-137204753 (+)
LP/J	MGP_LPJ_G0028942	protein coding gene	Chr4:143929106-143973773 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028836	protein coding gene	Chr4:157103480-157145159 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029494	protein coding gene	Chr4:142160364-142204370 (+)
PWK/PhJ	MGP_PWKPhJ_G0027882	protein coding gene	Chr4:134934896-134978277 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027707	protein coding gene	Chr4:137994675-138035535 (+)
WSB/EiJ	MGP_WSBEiJ_G0028239	protein coding gene	Chr4:142447222-142489060 (+)

Human Ortholog

PADI2, peptidyl arginine deiminase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PADI2, peptidyl arginine deiminase 2
Synonyms

PAD2, PAD-H19, PDI2
Links

HGNC:18341

NCBI Gene ID: 11240

neXtProt AC: NX_Q9Y2J8

UniProt: Q9Y2J8
Chr Location

1p36.13; chr1:17066761-17119451 (-) GRCh38

MGI Vertebrate Homology

Padi2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PADI2
Protein SuperFamily

Protein-arginine_deiminase
Gene Tree

Padi2

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Phenotype Summary

4 phenotypes from 2 alleles in 3 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Chemically induced (other)

2
Endonuclease-mediated

7
Gene trapped

15
Targeted

5
Genomic Mutations

3 involving Padi2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired ATP- or calcium ionophore ionomycin-induced citrullination of mast cells or of proteins following induction of EAE.

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All GO Annotations

33
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

903
Tissues

129
cDNA Data

15
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase padi2

ZFIN padi2

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All Sequences

45
RefSeq

4
UniProt

3
CCDS

CCDS18857.1

Ensembl

ENSMUSG00000028927 (Evidence)
NCBI Gene

18600

			Length	Strain/Species	Flank
genomic	18600	NCBI Gene Model \| MGI Sequence Detail	46213	C57BL/6J	± kb
transcript	NM_001421260	RefSeq \| MGI Sequence Detail	4810	ZRU/MplStud
polypeptide	Q08642	UniProt \| EBI \| MGI Sequence Detail	673	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012220 protein-arginine deiminase type-2

(term hierarchy)
EC

3.5.3.15
InterPro Domains

IPR008972 Cupredoxin

IPR038685 PAD, N-terminal domain superfamily

IPR004303 Protein-arginine deiminase

IPR036556 Protein-arginine deiminase, central domain superfamily

IPR013530 Protein-arginine deiminase, C-terminal

IPR013733 Protein-arginine deiminase (PAD), central domain

IPR013732 Protein-arginine deiminase (PAD), N-terminal
GlyGen

Q08642 1 site, 1 O-linked glycan (1 site)

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All nucleic 23

cDNA 16

Primer pair 6

Other 1

Microarray probesets 3

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MGD-MRK-13221, MGI:97534

Summaries

All 74

Developmental Gene Expression 7

Gene Ontology 9

Phenotypes 23
Earliest

J:22129 Takahara H, et al., Peptidylarginine deiminase of the mouse. Distribution, properties, and immunocytochemical localization. J Biol Chem. 1989 Aug 5;264(22):13361-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Padi2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39995	Chr4:140633646-140633664 (+)	-30 bp
Tssr39996	Chr4:140633675-140633693 (+)	-1 bp
Tssr39997	Chr4:140651549-140651569 (+)	17,874 bp
Tssr39998	Chr4:140651570-140651591 (+)	17,896 bp
Tssr39999	Chr4:140651599-140651622 (+)	17,926 bp
Tssr40000	Chr4:140672691-140672743 (+)	39,032 bp
Tssr40001	Chr4:140673585-140673594 (+)	39,905 bp
Tssr40002	Chr4:140677373-140677390 (+)	43,697 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24