Ogt MGI Mouse Gene Detail - MGI:1339639 - O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

Symbol

Ogt
Name

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
Synonyms

1110038P24Rik, 4831420N21Rik, OGT, Ogtl

Feature Type

protein coding gene
IDs

MGI:1339639
NCBI Gene: 108155
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

ChrX:100683666-100727957 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 44.45 cM, cytoband D
Mapping Data

4 experiments

SNPs within 2kb

668 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1339639	protein coding gene	ChrX:100683617-100727957 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035964	protein coding gene	ChrX:98168928-98218732 (+)
A/J	MGP_AJ_G0035949	protein coding gene	ChrX:98156303-98202472 (+)
AKR/J	MGP_AKRJ_G0035865	protein coding gene	ChrX:100986403-101037145 (+)
BALB/cJ	MGP_BALBcJ_G0035932	protein coding gene	ChrX:96903836-96949831 (+)
C3H/HeJ	MGP_C3HHeJ_G0035641	protein coding gene	ChrX:98566291-98615931 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036461	protein coding gene	ChrX:101082273-101130712 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033291	protein coding gene	ChrX:95894984-95938177 (+)
CAST/EiJ	MGP_CASTEiJ_G0034928	protein coding gene	ChrX:82873011-82920427 (+)
CBA/J	MGP_CBAJ_G0035616	protein coding gene	ChrX:104216471-104269145 (+)
DBA/2J	MGP_DBA2J_G0035770	protein coding gene	ChrX:97370338-97414576 (+)
FVB/NJ	MGP_FVBNJ_G0035708	protein coding gene	ChrX:96747188-96796591 (+)
LP/J	MGP_LPJ_G0035860	protein coding gene	ChrX:99116266-99163715 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035743	protein coding gene	ChrX:108754393-108808246 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036488	protein coding gene	ChrX:97849394-97897102 (+)
PWK/PhJ	MGP_PWKPhJ_G0034627	protein coding gene	ChrX:80472887-80517271 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034455	protein coding gene	ChrX:83789315-83839379 (+)
WSB/EiJ	MGP_WSBEiJ_G0035067	protein coding gene	ChrX:96558984-96602720 (+)

Human Ortholog

OGT, O-linked N-acetylglucosamine (GlcNAc) transferase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OGT, O-linked N-acetylglucosamine (GlcNAc) transferase
Synonyms

HINCUT-1, HRNT1, MRX106, O-GLCNAC, OGT1, XLID106
Links

HGNC:8127

NCBI Gene ID: 8473

neXtProt AC: NX_O15294

UniProt: O15294
Chr Location

Xq13.1; chrX:71533087-71575892 (+) GRCh38

MGI Vertebrate Homology

Ogt stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: OGT
Gene Tree

Ogt

Diseases

1 with Ogt mouse models; 1 with human OGT associations

Human Disease

Mouse Models

congenital disorder of glycosylation

IDs

View 1 model

non-syndromic X-linked intellectual disability 106

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

30 phenotypes from 3 alleles in 5 genetic backgrounds
1 images
72 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

5
Gene trapped

8
Targeted

1
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Conditional deletion of this gene results in cell death in hemizygous and homozygous cells. Following germline conditional deletion only females inheriting the deletion paternally survive.

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All GO Annotations

125
GO References

26

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

850
Tissues

104
cDNA Data

22
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ogt

ZFIN ogt.1

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All Sequences

68
RefSeq

8
UniProt

4
CCDS

CCDS30318.1, CCDS72415.1

Ensembl

ENSMUSG00000034160 (Evidence)
NCBI Gene

108155

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034160	Ensembl Gene Model \| MGI Sequence Detail	44292	C57BL/6J	± kb
transcript	ENSMUST00000044475	Ensembl \| MGI Sequence Detail	5384	Not Applicable
polypeptide	ENSMUSP00000045409	Ensembl \| MGI Sequence Detail	1046	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011618 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

(term hierarchy)
EC

2.4.1.255, 2.4.1.94
InterPro Domains

IPR029489 O-GlcNAc transferase, C-terminal

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat
GlyGen

Q8CGY8 8 sites, 1 O-linked glycan (7 sites)

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All nucleic 30

cDNA 25

Primer pair 4

Other 1

Microarray probesets 7

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MGD-MRK-39587, MGI:109588, MGI:1923575, MGI:1924387, MGI:2147844

Summaries

All 146

Developmental Gene Expression 16

Diseases 1

Gene Ontology 26

Phenotypes 72
Earliest

J:39462 Kreppel LK, et al., Dynamic glycosylation of nuclear and cytosolic proteins. Cloning and characterization of a unique O-GlcNAc transferase with multiple tetratricopeptide repeats. J Biol Chem. 1997 Apr 4;272(14):9308-15
Latest

J:358134 Soma S, et al., O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation. Stem Cells. 2024 Jan 13;42(1):55-63

TSS for Ogt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161681	ChrX:100683662-100683714 (+)	22 bp
Tssr161682	ChrX:100684664-100684675 (+)	1,004 bp
Tssr161683	ChrX:100692992-100693007 (+)	9,334 bp
Tssr161684	ChrX:100695964-100695981 (+)	12,307 bp
Tssr161685	ChrX:100695992-100696017 (+)	12,339 bp
Tssr161686	ChrX:100696081-100696093 (+)	12,421 bp
Tssr161687	ChrX:100696108-100696121 (+)	12,449 bp
Tssr161688	ChrX:100696136-100696168 (+)	12,486 bp
Tssr161689	ChrX:100696212-100696251 (+)	12,566 bp
Tssr161690	ChrX:100696310-100696337 (+)	12,658 bp
Tssr161691	ChrX:100696830-100696843 (+)	13,171 bp
Tssr161692	ChrX:100697075-100697164 (+)	13,454 bp
Tssr161693	ChrX:100697224-100697230 (+)	13,561 bp
Tssr161694	ChrX:100699156-100699166 (+)	15,495 bp
Tssr161695	ChrX:100710950-100710968 (+)	27,293 bp
Tssr161696	ChrX:100716645-100716678 (+)	32,996 bp
Tssr161697	ChrX:100723667-100723683 (+)	40,009 bp
Tssr161698	ChrX:100726542-100726554 (+)	42,882 bp
Tssr161699	ChrX:100726746-100726765 (+)	43,090 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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