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Csf2 Gene Detail
Summary
  • Symbol
    Csf2
  • Name
    colony stimulating factor 2 (granulocyte-macrophage)
  • Synonyms
    Csfgm, Gm-CSf, GMCSF, MGI-IGM
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339752
    NCBI Gene: 12981
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:54138097-54140493 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 32.13 cM
  • Mapping Data
    59 experiments
Strain
Comparison
more
  • SNPs within 2kb
    135 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    9
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339752
 protein coding gene Chr11:54138096-54140725 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018312
 protein coding gene Chr11:53716541-53718958 (-)
A/J MGP_AJ_G0018281
 protein coding gene Chr11:51708674-51711091 (-)
AKR/J MGP_AKRJ_G0018250
 protein coding gene Chr11:53401294-53403690 (-)
BALB/cJ MGP_BALBcJ_G0018252
 protein coding gene Chr11:52051320-52053716 (-)
C3H/HeJ MGP_C3HHeJ_G0018063
 protein coding gene Chr11:53339268-53341685 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018704
 protein coding gene Chr11:55367746-55370142 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016354
 protein coding gene Chr11:49173434-49175788 (-)
CAST/EiJ MGP_CASTEiJ_G0017628
 protein coding gene Chr11:53388181-53390553 (-)
CBA/J MGP_CBAJ_G0018038
 protein coding gene Chr11:57990305-57992722 (-)
DBA/2J MGP_DBA2J_G0018147
 protein coding gene Chr11:51423256-51425673 (-)
FVB/NJ MGP_FVBNJ_G0018139
 protein coding gene Chr11:51066152-51068569 (-)
LP/J MGP_LPJ_G0018222
 protein coding gene Chr11:54165592-54168009 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018165
 protein coding gene Chr11:59205397-59207814 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018746
 protein coding gene Chr11:53422040-53424404 (-)
PWK/PhJ MGP_PWKPhJ_G0017401
 protein coding gene Chr11:51965616-51967986 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017196
 protein coding gene Chr11:53193177-53195546 (-)
WSB/EiJ MGP_WSBEiJ_G0017676
 protein coding gene Chr11:53050311-53052728 (-)



Homology
more
  • Human Ortholog
    CSF2, colony stimulating factor 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSF2, colony stimulating factor 2
  • Synonyms
    CSF, GMCSF
  • Links
    NCBI Gene ID: 1437
    neXtProt AC: NX_P04141
    UniProt: P04141

  • Chr Location
    5q31.1; chr5:132073789-132076170 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Csf2 mouse models; 5 with human CSF2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    64 phenotypes from 2 alleles in 5 genetic backgrounds
    34 phenotypes from multigenic genotypes
    183 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit lung abnormalities with lymphocytic infiltration and accumulation of surfactant lipids. Litter sizes from homozygous breeding pairs are smaller at weaning due to perinatal mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    37
  • cDNA Data
    13
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018916 Ensembl Gene Model | MGI Sequence Detail 2397 C57BL/6J ±  kb
    transcript ENSMUST00000019060 Ensembl | MGI Sequence Detail 800 Not Applicable  
    polypeptide ENSMUSP00000019060 Ensembl | MGI Sequence Detail 141 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 14
      cDNA 13
      Primer pair 13
      Other 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-2187, MGI:88531
    References
    more
    • Summaries
      All 442
      Developmental Gene Expression 14
      Diseases 3
      Gene Ontology 16
      Phenotypes 183
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:350668 Wohner M, et al., Tissue niche occupancy determines the contribution of fetal- versus bone-marrow-derived macrophages to IgG effector functions. Cell Rep. 2024 Feb 27;43(2):113757
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory