Tbpl1 MGI Mouse Gene Detail - MGI:1339946 - TATA box binding protein-like 1

Symbol

Tbpl1
Name

TATA box binding protein-like 1
Synonyms

TLF, Tlp, TRF2, TRP

Feature Type

protein coding gene
IDs

MGI:1339946
NCBI Gene: 237336
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:22579778-22607837 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 10.25 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

656 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1339946	protein coding gene	Chr10:22579776-22607882 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017069	protein coding gene	Chr10:20633977-20662031 (-)
A/J	MGP_AJ_G0017047	protein coding gene	Chr10:20018209-20047163 (-)
AKR/J	MGP_AKRJ_G0017009	protein coding gene	Chr10:20339664-20370484 (-)
BALB/cJ	MGP_BALBcJ_G0017009	protein coding gene	Chr10:20091357-20119340 (-)
C3H/HeJ	MGP_C3HHeJ_G0016829	protein coding gene	Chr10:20568772-20595177 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017467	protein coding gene	Chr10:21205287-21238593 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015168	protein coding gene	Chr10:18824124-18852613 (-)
CAST/EiJ	MGP_CASTEiJ_G0016410	protein coding gene	Chr10:20434616-20468297 (-)
CBA/J	MGP_CBAJ_G0016802	protein coding gene	Chr10:22186702-22218207 (-)
DBA/2J	MGP_DBA2J_G0016908	protein coding gene	Chr10:19769057-19798045 (-)
FVB/NJ	MGP_FVBNJ_G0016904	protein coding gene	Chr10:19489028-19517610 (-)
LP/J	MGP_LPJ_G0016984	protein coding gene	Chr10:20576567-20604404 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016934	protein coding gene	Chr10:22355749-22388976 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017502	protein coding gene	Chr10:20194554-20223081 (-)
PWK/PhJ	MGP_PWKPhJ_G0016195	protein coding gene	Chr10:19528261-19556638 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015976	protein coding gene	Chr10:20005866-20036147 (-)
WSB/EiJ	MGP_WSBEiJ_G0016473	protein coding gene	Chr10:20300897-20330903 (-)

Human Ortholog

TBPL1, TATA-box binding protein like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TBPL1, TATA-box binding protein like 1
Synonyms

MGC:8389, MGC:9620, STUD, TLF, TLP, TRF2
Links

HGNC:11589

NCBI Gene ID: 9519

neXtProt AC: NX_P62380

UniProt: P62380
Chr Location

6q23.2; chr6:133952170-133990432 (+) GRCh38

MGI Vertebrate Homology

Tbpl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TBPL1
Gene Tree

Tbpl1

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Targeted

5
Genomic Mutations

1 involving Tbpl1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Males homozygous for targeted null mutations are sterile due to a block in spermiogenesis. Spermatids exhibit defective acrosome formation, fragmentation of the chromocenter, and develop at most to step 7 of differentiation.

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All GO Annotations

20
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

865
Tissues

78
cDNA Data

80
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tbpl1

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All Sequences

58
RefSeq

14
UniProt

2
CCDS

CCDS23730.1

Ensembl

ENSMUSG00000071359 (Evidence)
NCBI Gene

237336

			Length	Strain/Species	Flank
genomic	ENSMUSG00000071359	Ensembl Gene Model \| MGI Sequence Detail	28060	C57BL/6J	± kb
transcript	ENSMUST00000095794	Ensembl \| MGI Sequence Detail	1195	Not Applicable
polypeptide	ENSMUSP00000093470	Ensembl \| MGI Sequence Detail	186	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016138 TATA box-binding protein-like 1

(term hierarchy)
InterPro Domains

IPR000814 TATA-box binding protein

IPR015445 TATA-Box binding protein-like 1

IPR012295 TBP domain superfamily

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All nucleic 85

cDNA 80

Primer pair 4

Other 1

Microarray probesets 6

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MGI:2143790, MGI:2143841, MGI:2143952

Summaries

All 67

Developmental Gene Expression 14

Gene Ontology 10

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:292511 Gustafson EA, et al., ZFP628 Is a TAF4b-Interacting Transcription Factor Required for Mouse Spermiogenesis. Mol Cell Biol. 2020 Mar 16;40(7)

TSS for Tbpl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr97047	Chr10:22607858-22607888 (-)	-36 bp
Tssr97046	Chr10:22607817-22607845 (-)	6 bp
Tssr97045	Chr10:22607773-22607815 (-)	43 bp
Tssr97044	Chr10:22607753-22607771 (-)	75 bp
Tssr97043	Chr10:22607732-22607748 (-)	97 bp
Tssr97039	Chr10:22580182-22580183 (-)	27,654 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24