Nfe2l3 MGI Mouse Gene Detail - MGI:1339958 - nuclear factor, erythroid derived 2, like 3

Symbol

Nfe2l3
Name

nuclear factor, erythroid derived 2, like 3
Synonyms

Nrf3

Feature Type

protein coding gene
IDs

MGI:1339958
NCBI Gene: 18025
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr6:51409650-51435748 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 24.84 cM
Mapping Data

3 experiments

SNPs within 2kb

814 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1339958	protein coding gene	Chr6:51409649-51435752 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030733	protein coding gene	Chr6:50617686-50647406 (+)
A/J	MGP_AJ_G0030703	protein coding gene	Chr6:48249373-48281343 (+)
AKR/J	MGP_AKRJ_G0030629	protein coding gene	Chr6:49937057-49965729 (+)
BALB/cJ	MGP_BALBcJ_G0030714	protein coding gene	Chr6:48610840-48637044 (+)
C3H/HeJ	MGP_C3HHeJ_G0030428	protein coding gene	Chr6:49953037-49983253 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031169	protein coding gene	Chr6:51738150-51769270 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028376	protein coding gene	Chr6:45927687-45953205 (+)
CAST/EiJ	MGP_CASTEiJ_G0029830	protein coding gene	Chr6:49722163-49751330 (+)
CBA/J	MGP_CBAJ_G0030401	protein coding gene	Chr6:53910746-53939088 (+)
DBA/2J	MGP_DBA2J_G0030551	protein coding gene	Chr6:48179327-48206012 (+)
FVB/NJ	MGP_FVBNJ_G0030503	protein coding gene	Chr6:47797698-47825022 (+)
LP/J	MGP_LPJ_G0030636	protein coding gene	Chr6:50587283-50616117 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030537	protein coding gene	Chr6:56568167-56597258 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031199	protein coding gene	Chr6:49855003-49884598 (+)
PWK/PhJ	MGP_PWKPhJ_G0029543	protein coding gene	Chr6:47780819-47807988 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029378	protein coding gene	Chr6:49191670-49224507 (+)
WSB/EiJ	MGP_WSBEiJ_G0029907	protein coding gene	Chr6:49843714-49871609 (+)

Human Ortholog

NFE2L3, NFE2 like bZIP transcription factor 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NFE2L3, NFE2 like bZIP transcription factor 3
Synonyms

NRF3
Links

HGNC:7783

NCBI Gene ID: 9603

neXtProt AC: NX_Q9Y4A8

UniProt: Q9Y4A8
Chr Location

7p15.2; chr7:26152198-26187137 (+) GRCh38

MGI Vertebrate Homology

Nfe2l3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NFE2L3
Gene Tree

Nfe2l3

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
7 phenotype references

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available

Mice homozygous for disruptions in this gene display a normal phenotype.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

774
Tissues

29
cDNA Data

41
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nfe2l3

ZFIN nfe2l3

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All Sequences

45
RefSeq

2
UniProt

8
CCDS

CCDS20134.1

Ensembl

ENSMUSG00000029832 (Evidence)
NCBI Gene

18025

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029832	Ensembl Gene Model \| MGI Sequence Detail	26099	C57BL/6J	± kb
transcript	ENSMUST00000005103	Ensembl \| MGI Sequence Detail	2544	Not Applicable
polypeptide	ENSMUSP00000005103	Ensembl \| MGI Sequence Detail	660	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000011171 nuclear factor erythroid 2-related factor 3

(term hierarchy)
InterPro Domains

IPR004827 Basic-leucine zipper domain

IPR004826 Basic leucine zipper domain, Maf-type

IPR046347 Basic-leucine zipper domain superfamily

IPR047167 Nuclear Factor Erythroid-derived 2-like

IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamily

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All nucleic 43

cDNA 41

Primer pair 1

Other 1

Microarray probesets 5

Summaries

All 47

Developmental Gene Expression 12

Gene Ontology 4

Phenotypes 7
Earliest

J:53336 Kobayashi A, et al., Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. J Biol Chem. 1999 Mar 5;274(10):6443-52
Latest

J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893

TSS for Nfe2l3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56435	Chr6:51409643-51409654 (+)	-1 bp
Tssr56436	Chr6:51409658-51409764 (+)	61 bp
Tssr56437	Chr6:51409803-51409814 (+)	159 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24