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Ftcd Gene Detail
Summary
  • Symbol
    Ftcd
  • Name
    formiminotransferase cyclodeaminase
  • Synonyms
    glutamate formiminotransferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339962
    NCBI Gene: 14317
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
  • Candidate for QTL
    3 QTL
Location &
Maps
more
  • Sequence Map
    Chr10:76411482-76426172 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.25 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    521 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339962
 protein coding gene Chr10:76411482-76426172 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017387
 protein coding gene Chr10:76829175-76845363 (+)
A/J MGP_AJ_G0017364
 protein coding gene Chr10:74169745-74184260 (+)
AKR/J MGP_AKRJ_G0017325
 protein coding gene Chr10:76168470-76184394 (+)
BALB/cJ MGP_BALBcJ_G0017324
 protein coding gene Chr10:74372895-74388807 (+)
C3H/HeJ MGP_C3HHeJ_G0017148
 protein coding gene Chr10:76247130-76264267 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017782
 protein coding gene Chr10:79531805-79548775 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015472
 protein coding gene Chr10:70614267-70628998 (+)
CAST/EiJ MGP_CASTEiJ_G0016718
 protein coding gene Chr10:76566125-76582060 (+)
CBA/J MGP_CBAJ_G0017120
 protein coding gene Chr10:82647766-82666222 (+)
DBA/2J MGP_DBA2J_G0017225
 protein coding gene Chr10:73471283-73486392 (+)
FVB/NJ MGP_FVBNJ_G0017217
 protein coding gene Chr10:72629371-72645443 (+)
LP/J MGP_LPJ_G0017298
 protein coding gene Chr10:77309689-77328430 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017246
 protein coding gene Chr10:84700263-84719145 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017821
 protein coding gene Chr10:76230321-76245970 (+)
PWK/PhJ MGP_PWKPhJ_G0016502
 protein coding gene Chr10:73319173-73334531 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016285
 protein coding gene Chr10:75454682-75469085 (+)
WSB/EiJ MGP_WSBEiJ_G0016781
 protein coding gene Chr10:76205399-76221041 (+)



Homology
more
  • Human Ortholog
    FTCD, formimidoyltransferase cyclodeaminase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FTCD, formimidoyltransferase cyclodeaminase
  • Synonyms
    LCHC1
  • Links
    NCBI Gene ID: 10841
    neXtProt AC: NX_O95954
    UniProt: O95954

  • Chr Location
    21q22.3; chr21:46136160-46155579 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FTCD associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    872
  • Tissues
    136
  • cDNA Data
    41
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14317 NCBI Gene Model | MGI Sequence Detail 14691 C57BL/6J ±  kb
transcript NM_080845 RefSeq | MGI Sequence Detail 2710 ZRU/MplStud  
polypeptide Q91XD4 UniProt | EBI | MGI Sequence Detail 541 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007689 formimidoyltransferase-cyclodeaminase
    (term hierarchy)
  • EC
    2.1.2.5, 4.3.1.4
  • InterPro Domains
    IPR007044 Cyclodeaminase/cyclohydrolase
    IPR036178 Formimidoyltransferase-cyclodeaminase-like superfamily
    IPR004227 Formiminotransferase catalytic domain
    IPR022384 Formiminotransferase catalytic domain superfamily
    IPR013802 Formiminotransferase, C-terminal subdomain
    IPR037070 Formiminotransferase, C-terminal subdomain superfamily
    IPR051623 Formiminotransferase-cyclodeaminase
    IPR012886 Formiminotransferase, N-terminal subdomain
    IPR037064 Formiminotransferase, N-terminal subdomain superfamily
  • GlyGen
    Q91XD4 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 45
    Genomic 1
    cDNA 41
    Primer pair 3

    Microarray probesets 3
References
more
  • Summaries
    All 75
    Developmental Gene Expression 8
    Diseases 2
    Gene Ontology 8
    Phenotypes 37
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:351211 Wu Y, et al., Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B. Acta Neuropathol Commun. 2023 Aug 14;11(1):132
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory