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St3gal5 Gene Detail
Summary
  • Symbol
    St3gal5
  • Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 5
  • Synonyms
    3S-T, [a]2, GM3-specific sialytransferase, GM3 synthase, mST3Gal V, Siat9, ST3Gal V
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339963
    NCBI Gene: 20454
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:72074576-72131555 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 32.24 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1605 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339963
 protein coding gene Chr6:72074555-72131555 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030867
 protein coding gene Chr6:72611241-72678376 (+)
A/J MGP_AJ_G0030837
 protein coding gene Chr6:69817461-69873134 (+)
AKR/J MGP_AKRJ_G0030766
 protein coding gene Chr6:71853994-71916713 (+)
BALB/cJ MGP_BALBcJ_G0030848
 protein coding gene Chr6:69844597-69901637 (+)
C3H/HeJ MGP_C3HHeJ_G0030864
 protein coding gene Chr6:112315345-112372722 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031306
 protein coding gene Chr6:74533467-74601689 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028495
 protein coding gene Chr6:68963652-69020239 (+)
CAST/EiJ MGP_CASTEiJ_G0029956
 protein coding gene Chr6:71719047-71777370 (+)
CBA/J MGP_CBAJ_G0030535
 protein coding gene Chr6:77552097-77617377 (+)
DBA/2J MGP_DBA2J_G0030687
 protein coding gene Chr6:69213349-69270556 (+)
FVB/NJ MGP_FVBNJ_G0030640
 protein coding gene Chr6:68580995-68637483 (+)
LP/J MGP_LPJ_G0030766
 protein coding gene Chr6:72534243-72594685 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030675
 protein coding gene Chr6:80965590-81028421 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031332
 protein coding gene Chr6:71669509-71731495 (+)
PWK/PhJ MGP_PWKPhJ_G0029672
 protein coding gene Chr6:68110032-68167489 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029500
 protein coding gene Chr6:70409183-70465761 (+)
WSB/EiJ MGP_WSBEiJ_G0030038
 protein coding gene Chr6:72037909-72100283 (+)



Homology
more
  • Human Ortholog
    ST3GAL5, ST3 beta-galactoside alpha-2,3-sialyltransferase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST3GAL5, ST3 beta-galactoside alpha-2,3-sialyltransferase 5
  • Synonyms
    SATI, SIAT9, SIATGM3S, SPDRS, ST3Gal V, ST3GalV
  • Links
    NCBI Gene ID: 8869
    neXtProt AC: NX_Q9UNP4
    UniProt: Q9UNP4

  • Chr Location
    2p11.2; chr2:85837120-85905199 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ST3GAL5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    20 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted inactivation of this gene leads to inability to synthesize GM3 ganglioside. Homozygotes for a null allele exhibit enhanced sensitivity to insulin. Homozygotes for a different null allele show resistance to botulinum neurotoxin type C.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    861
  • Tissues
    153
  • cDNA Data
    47
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056091 Ensembl Gene Model | MGI Sequence Detail 56980 C57BL/6J ±  kb
    transcript ENSMUST00000069994 Ensembl | MGI Sequence Detail 2258 Not Applicable  
    polypeptide ENSMUSP00000070414 Ensembl | MGI Sequence Detail 414 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 47
      Primer pair 4

      Microarray probesets 4
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 41
    • Earliest
      J:55319 Kono M, et al., Molecular cloning and functional expression of a fifth-type alpha 2,3-sialyltransferase (mST3Gal V: GM3 synthase). Biochem Biophys Res Commun. 1998 Dec 9;253(1):170-5
    • Latest
      J:343663 Takeda K, et al., Chronic encephalomyelitis virus exhibits cellular tropism and evades pDCs by binding to sialylated integrins as the cell surface receptors. Eur J Immunol. 2023 Oct;53(10):e2350452
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory