Tesmin MGI Mouse Gene Detail - MGI:1340029 - testis expressed metallothionein like

Symbol

Tesmin
Name

testis expressed metallothionein like
Synonyms

Mtl5, tesmin

Feature Type

protein coding gene
IDs

MGI:1340029
NCBI Gene: 17771
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr19:3438857-3457823 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 3.15 cM, cytoband B
Mapping Data

2 experiments

SNPs within 2kb

487 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1340029	protein coding gene	Chr19:3438857-3457823 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024624	protein coding gene	Chr19:146180-164393 (+)
A/J	MGP_AJ_G0024591	protein coding gene	Chr19:156946-175353 (+)
AKR/J	MGP_AKRJ_G0024562	protein coding gene	Chr19:143525-161710 (+)
BALB/cJ	MGP_BALBcJ_G0024589	protein coding gene	Chr19:142298-160521 (+)
C3H/HeJ	MGP_C3HHeJ_G0024358	protein coding gene	Chr19:147233-165438 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025037	protein coding gene	Chr19:134304-153253 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022466	protein coding gene	Chr19:135369-154224 (+)
CAST/EiJ	MGP_CASTEiJ_G0023830	protein coding gene	Chr19:143286-161415 (+)
CBA/J	MGP_CBAJ_G0024328	protein coding gene	Chr19:166892-185101 (+)
DBA/2J	MGP_DBA2J_G0024457	protein coding gene	Chr19:138346-156781 (+)
FVB/NJ	MGP_FVBNJ_G0024424	protein coding gene	Chr19:140171-158389 (+)
LP/J	MGP_LPJ_G0024543	protein coding gene	Chr19:145995-164207 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024454	protein coding gene	Chr19:156486-174799 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025085	protein coding gene	Chr19:136906-155120 (+)
PWK/PhJ	MGP_PWKPhJ_G0023576	protein coding gene	Chr19:147361-166487 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023382	protein coding gene	Chr19:137345-155416 (+)
WSB/EiJ	MGP_WSBEiJ_G0023893	protein coding gene	Chr19:141500-160404 (+)

Human Ortholog

TESMIN, testis expressed metallothionein like protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TESMIN, testis expressed metallothionein like protein
Synonyms

CXCDC2, MTL5, MTLT
Links

HGNC:7446

NCBI Gene ID: 9633

neXtProt AC: NX_Q9Y4I5

UniProt: Q9Y4I5
Chr Location

11q13.3; chr11:68704796-68751520 (-) GRCh38

MGI Vertebrate Homology

Tesmin stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TESMIN
Gene Tree

Tesmin

less

Phenotype Summary

8 phenotypes from 3 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

3
Gene trapped

1
Targeted

3
Transgenic

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutations of this gene lead to male infertility due to arrested spermatogenesis at the pachytene stage. Male mice expressing a truncated protein that cannot interact with LIN9 phenocopy the defects observed in homozygous null males.

less

All GO Annotations

8
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

785
Tissues

26
cDNA Data

18
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN tesmin

less

All Sequences

49
RefSeq

8
UniProt

2
CCDS

CCDS37880.1, CCDS50339.1, CCDS70912.1

Ensembl

ENSMUSG00000024905 (Evidence)
NCBI Gene

17771

			Length	Strain/Species	Flank
genomic	17771	NCBI Gene Model \| MGI Sequence Detail	18967	C57BL/6J	± kb
transcript	NM_001286557	RefSeq \| MGI Sequence Detail	2318	C57BL/6
polypeptide	Q9WTJ6	UniProt \| EBI \| MGI Sequence Detail	475	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000010729 tesmin

(term hierarchy)
InterPro Domains

IPR005172 CRC domain

IPR028307 Lin-54 family

IPR033467 Tesmin/TSO1-like CXC domain

less

All nucleic 24

Genomic 1

cDNA 20

Primer pair 1

Other 2

Microarray probesets 5

less

MGI:5883606

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 7
Earliest

J:54627 Sugihara T, et al., A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation. Genomics. 1999 Apr 1;57(1):130-6
Latest

J:336504 Oura S, et al., Proximity-dependent biotin labeling in testicular germ cells identified TESMIN-associated proteins. Sci Rep. 2022 Dec 23;12(1):22198

TSS for Tesmin:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154183	Chr19:3438861-3438904 (+)	26 bp
Tssr154184	Chr19:3438922-3438931 (+)	70 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24