Crlf1 MGI Mouse Gene Detail - MGI:1340030 - cytokine receptor-like factor 1

Symbol

Crlf1
Name

cytokine receptor-like factor 1
Synonyms

CLF-1, CRLM3, cytokine receptor like molecule 3

Feature Type

protein coding gene
IDs

MGI:1340030
NCBI Gene: 12931
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:70945808-70956731 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 34.15 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

157 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1340030	protein coding gene	Chr8:70945798-70956731 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033707	protein coding gene	Chr8:70761464-70772368 (+)
A/J	MGP_AJ_G0033690	protein coding gene	Chr8:67889884-67901355 (+)
AKR/J	MGP_AKRJ_G0033615	protein coding gene	Chr8:69818790-69829712 (+)
BALB/cJ	MGP_BALBcJ_G0033686	protein coding gene	Chr8:68107665-68118569 (+)
C3H/HeJ	MGP_C3HHeJ_G0033396	protein coding gene	Chr8:70464385-70475460 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034203	protein coding gene	Chr8:73436472-73451988 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031147	protein coding gene	Chr8:62704925-62715983 (+)
CAST/EiJ	MGP_CASTEiJ_G0032721	protein coding gene	Chr8:69950148-69961059 (+)
CBA/J	MGP_CBAJ_G0033374	protein coding gene	Chr8:76071705-76082609 (+)
DBA/2J	MGP_DBA2J_G0033528	protein coding gene	Chr8:67607947-67618851 (+)
FVB/NJ	MGP_FVBNJ_G0033469	protein coding gene	Chr8:66723405-66734309 (+)
LP/J	MGP_LPJ_G0033615	protein coding gene	Chr8:70788515-70799457 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033512	protein coding gene	Chr8:78748737-78759632 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034221	protein coding gene	Chr8:70006901-70017805 (+)
PWK/PhJ	MGP_PWKPhJ_G0032429	protein coding gene	Chr8:66906035-66917040 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032265	protein coding gene	Chr8:68971367-68982277 (+)
WSB/EiJ	MGP_WSBEiJ_G0032836	protein coding gene	Chr8:70365404-70376324 (+)

Human Ortholog

CRLF1, cytokine receptor like factor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRLF1, cytokine receptor like factor 1
Synonyms

CISS, CISS1, CLF, CLF-1, NR6, zcytor5
Links

HGNC:2364

NCBI Gene ID: 9244

neXtProt AC: NX_O75462

UniProt: O75462
Chr Location

19p13.11; chr19:18572220-18607741 (-) GRCh38

MGI Vertebrate Homology

Crlf1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CRLF1
Gene Tree

Crlf1

Diseases

1 with human CRLF1 associations

				Human Disease	Mouse Models
				cold-induced sweating syndrome 1 IDs cold-induced sweating syndrome 1 DOID:0080329 OMIM:272430

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Targeted

2
Genomic Mutations

1 involving Crlf1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available

Mice homozygous for a targeted mutation fail to suckle effectively and do not survive beyond 24 hrs after birth. Newborns exhibit reduced numbers of hematopoietic progenitor cells as well as a significant reduction in the number of motoneurons in the lumbar spinal cord and facial nucleus.

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All GO Annotations

24
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

921
Tissues

77
cDNA Data

33
Literature Summary

21

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase crlf1

ZFIN crlf1a, crlf1b

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All Sequences

63
RefSeq

17
UniProt

6
CCDS

CCDS22369.1

Ensembl

ENSMUSG00000007888 (Evidence)
NCBI Gene

12931

			Length	Strain/Species	Flank
genomic	ENSMUSG00000007888	Ensembl Gene Model \| MGI Sequence Detail	10924	C57BL/6J	± kb
transcript	ENSMUST00000008032	Ensembl \| MGI Sequence Detail	1644	Not Applicable
polypeptide	ENSMUSP00000008032	Ensembl \| MGI Sequence Detail	425	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000005885 cytokine receptor-like factor 1

(term hierarchy)
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR015152 Growth hormone/erythropoietin receptor, ligand binding

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR050379 Type I Cytokine Receptor
GlyGen

Q9JM58 6 sites, 3 N-linked glycans (4 sites)

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All nucleic 39

cDNA 33

Primer pair 5

Other 1

Microarray probesets 4

Summaries

All 56

Developmental Gene Expression 21

Gene Ontology 6

Phenotypes 9
Earliest

J:61516 Elson GC, et al., Cytokine-like factor-1, a novel soluble protein, shares homology with members of the cytokine type I receptor family. J Immunol. 1998 Aug 1;161(3):1371-9
Latest

J:329983 Fidalgo MF, et al., Aerocyte specification and lung adaptation to breathing is dependent on alternative splicing changes. Life Sci Alliance. 2022 Dec;5(12):e202201554

TSS for Crlf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77743	Chr8:70945767-70945778 (+)	-35 bp
Tssr77744	Chr8:70945790-70945804 (+)	-11 bp
Tssr77745	Chr8:70945806-70945817 (+)	4 bp
Tssr77746	Chr8:70951271-70951275 (+)	5,465 bp
Tssr77747	Chr8:70953766-70953822 (+)	7,986 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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