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Sema3e Gene Detail
Summary
  • Symbol
    Sema3e
  • Name
    sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
  • Synonyms
    mKIAA0331, Semah
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340034
    NCBI Gene: 20349
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:14075290-14306703 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 5.66 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7392 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1340034
 protein coding gene Chr5:14075290-14306703 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029296
 protein coding gene Chr5:11277832-11513857 (+)
A/J MGP_AJ_G0029260
 protein coding gene Chr5:10891780-11131562 (+)
AKR/J MGP_AKRJ_G0029210
 protein coding gene Chr5:11514904-11746562 (+)
BALB/cJ MGP_BALBcJ_G0029276
 protein coding gene Chr5:11370853-11601185 (+)
C3H/HeJ MGP_C3HHeJ_G0028997
 protein coding gene Chr5:11462058-11710855 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029728
 protein coding gene Chr5:12477077-12718986 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026969
 protein coding gene Chr5:9376239-9599006 (+)
CAST/EiJ MGP_CASTEiJ_G0028409
 protein coding gene Chr5:11226253-11470336 (+)
CBA/J MGP_CBAJ_G0028959
 protein coding gene Chr5:12341081-12595319 (+)
DBA/2J MGP_DBA2J_G0029112
 protein coding gene Chr5:11251902-11479307 (+)
FVB/NJ MGP_FVBNJ_G0029074
 protein coding gene Chr5:10701567-10933289 (+)
LP/J MGP_LPJ_G0029200
 protein coding gene Chr5:11638451-11873134 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029102
 protein coding gene Chr5:13118175-13389077 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029760
 protein coding gene Chr5:11100744-11353185 (+)
PWK/PhJ MGP_PWKPhJ_G0028131
 protein coding gene Chr5:10793078-11019178 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027964
 protein coding gene Chr5:11046399-11286018 (+)
WSB/EiJ MGP_WSBEiJ_G0028489
 protein coding gene Chr5:11096389-11341789 (+)



Homology
more
  • Human Ortholog
    SEMA3E, semaphorin 3E
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEMA3E, semaphorin 3E
  • Synonyms
    coll-5, M-SEMAH, M-SemaK, SEMAH
  • Links
    NCBI Gene ID: 9723
    neXtProt AC: NX_O15041
    UniProt: O15041

  • Chr Location
    7q21.11; chr7:83363238-83649139 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 4 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    4 images
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display abnormal intersomitic vacular development and loss of the normal segmented somite pattern. Homozygous mutants for another allele have Bergmeister papillae on the surface of the optic disc.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    796
  • Tissues
    40
  • cDNA Data
    31
  • Literature Summary
    50
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20349 NCBI Gene Model | MGI Sequence Detail 231414 C57BL/6J ±  kb
    transcript NM_011348 RefSeq | MGI Sequence Detail 6877 C57BL/6  
    polypeptide P70275 UniProt | EBI | MGI Sequence Detail 775 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 33
      Primer pair 2
      Other 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1097708, MGI:2143468
    References
    more
    • Summaries
      All 125
      Developmental Gene Expression 50
      Gene Ontology 9
      Phenotypes 49
    • Earliest
      J:46372 Christensen CR, et al., Transcription of a novel mouse semaphorin gene, M-semaH, correlates with the metastatic ability of mouse tumor cell lines. Cancer Res. 1998 Mar 15;58(6):1238-44
    • Latest
      J:349009 Kim N, et al., Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1. Elife. 2024 Mar 25;13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory