Cst9 MGI Mouse Gene Detail - MGI:1340053

Symbol

Cst9
Name

cystatin 9
Synonyms

cresp, M12, testatin

Feature Type

protein coding gene
IDs

MGI:1340053
NCBI Gene: 13013
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:148677067-148680657 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 73.58 cM, cytoband H1
Mapping Data

3 experiments

SNPs within 2kb

277 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1340053	protein coding gene	Chr2:148677067-148680658 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026618	protein coding gene	Chr2:153192849-153196440 (+)
A/J	MGP_AJ_G0026582	protein coding gene	Chr2:146952130-146957510 (+)
AKR/J	MGP_AKRJ_G0026556	protein coding gene	Chr2:151200640-151204231 (+)
BALB/cJ	MGP_BALBcJ_G0026594	protein coding gene	Chr2:147386076-147390117 (+)
C3H/HeJ	MGP_C3HHeJ_G0026337	protein coding gene	Chr2:151692562-151697485 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027039	protein coding gene	Chr2:157657890-157661481 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024417	protein coding gene	Chr2:140953745-140957314 (+)
CAST/EiJ	MGP_CASTEiJ_G0025798	protein coding gene	Chr2:152100173-152103763 (+)
CBA/J	MGP_CBAJ_G0026317	protein coding gene	Chr2:163427579-163431537 (+)
DBA/2J	MGP_DBA2J_G0026451	protein coding gene	Chr2:146222051-146226138 (+)
FVB/NJ	MGP_FVBNJ_G0026415	protein coding gene	Chr2:144718280-144722084 (+)
LP/J	MGP_LPJ_G0026555	protein coding gene	Chr2:153324284-153327875 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026435	protein coding gene	Chr2:167466980-167470564 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027094	protein coding gene	Chr2:151205256-151209835 (+)
PWK/PhJ	MGP_PWKPhJ_G0025534	protein coding gene	Chr2:145900027-145903611 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025335	protein coding gene	Chr2:150171374-150174959 (+)
WSB/EiJ	MGP_WSBEiJ_G0025872	protein coding gene	Chr2:152154206-152157794 (+)

Human Ortholog

CST9, cystatin 9

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CST9, cystatin 9
Synonyms

CLM, CTES7A
Links

HGNC:13261

NCBI Gene ID: 128822

neXtProt AC: NX_Q5W186

UniProt: Q5W186
Chr Location

20p11.21; chr20:23602410-23605917 (-) GRCh38

Human Ortholog

CST9L, cystatin 9 like
Synonyms

bA218C14.1, CTES7B
Links

HGNC:16233

NCBI Gene ID: 128821

neXtProt AC: NX_Q9H4G1

UniProt: Q9H4G1
Chr Location

20p11.21; chr20:23564732-23568484 (-) GRCh38

Human Ortholog

CST9LP1, cystatin 9-like pseudogene 1
Synonyms

CTES7C
Links

HGNC:39552

NCBI Gene ID: 128820

UniProt: Q5W188
Chr Location

20p11.21; chr20:23547764-23550652 (-) GRCh38

MGI Vertebrate Homology

Cst9 stringent orthology
3 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CST9, CST9L, CST9LP1
Gene Tree

Cst9

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Phenotype Summary

3 phenotypes from 3 alleles in 3 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

5
Genomic Mutations

3 involving Cst9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes are viable and fertile with normal testes development and morphology, sperm numbers and motility, and serum levels of testosterone, luteinizing hormone, and follicle-stimulating hormone.

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All GO Annotations

6
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

927
Tissues

73
cDNA Data

13
Literature Summary

18

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

29
RefSeq

2
UniProt

1
CCDS

CCDS16850.1

Ensembl

ENSMUSG00000027445 (Evidence)
NCBI Gene

13013

			Length	Strain/Species	Flank
genomic	13013	NCBI Gene Model \| MGI Sequence Detail	3591	C57BL/6J	± kb
transcript	NM_009979	RefSeq \| MGI Sequence Detail	687	Not Specified
polypeptide	Q9Z0H6	UniProt \| EBI \| MGI Sequence Detail	137	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005971 cystatin-9

(term hierarchy)
InterPro Domains

IPR043250 Cystatin-9-like

IPR000010 Cystatin domain

IPR046350 Cystatin superfamily
GlyGen

Q9Z0H6 2 sites

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All nucleic 24

cDNA 13

Primer pair 9

Other 2

Microarray probesets 4

Summaries

All 53

Developmental Gene Expression 18

Gene Ontology 5

Phenotypes 15
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cst9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20674	Chr2:148677036-148677045 (+)	-26 bp
Tssr20675	Chr2:148677060-148677113 (+)	20 bp
Tssr20676	Chr2:148677114-148677115 (+)	48 bp
Tssr20677	Chr2:148677117-148677147 (+)	65 bp
Tssr20678	Chr2:148677253-148677254 (+)	187 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24