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Cxcl2 Gene Detail
Summary
  • Symbol
    Cxcl2
  • Name
    C-X-C motif chemokine ligand 2
  • Synonyms
    CINC-2a, Gro2, GROb, Mgsa-b, Mip2, MIP-2, MIP-2a, Scyb, Scyb2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340094
    NCBI Gene: 20310
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:91051758-91053797 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 44.78 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    171 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1340094
 protein coding gene Chr5:91051730-91053797 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029732
 protein coding gene Chr5:91996280-91998347 (+)
A/J MGP_AJ_G0029698
 protein coding gene Chr5:88365243-88371217 (+)
AKR/J MGP_AKRJ_G0029644
 protein coding gene Chr5:91229050-91231117 (+)
BALB/cJ MGP_BALBcJ_G0029708
 protein coding gene Chr5:89270459-89272526 (+)
C3H/HeJ MGP_C3HHeJ_G0029431
 protein coding gene Chr5:91654357-91656424 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030162
 protein coding gene Chr5:95658254-95660321 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027398
 protein coding gene Chr5:84058935-84060988 (+)
CAST/EiJ MGP_CASTEiJ_G0028841
 protein coding gene Chr5:91016087-91017979 (+)
CBA/J MGP_CBAJ_G0029401
 protein coding gene Chr5:98954244-98956311 (+)
DBA/2J MGP_DBA2J_G0029545
 protein coding gene Chr5:88443587-88445654 (+)
FVB/NJ MGP_FVBNJ_G0029504
 protein coding gene Chr5:87291315-87293382 (+)
LP/J MGP_LPJ_G0029633
 protein coding gene Chr5:92377516-92379583 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029533
 protein coding gene Chr5:103925762-103927829 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030196
 protein coding gene Chr5:90780145-90782212 (+)
PWK/PhJ MGP_PWKPhJ_G0028560
 protein coding gene Chr5:87488999-87495281 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028395
 protein coding gene Chr5:90177765-90179846 (+)
WSB/EiJ MGP_WSBEiJ_G0028920
 protein coding gene Chr5:91225364-91227426 (+)



Homology
more
  • Human Ortholog
    CXCL1, C-X-C motif chemokine ligand 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CXCL1, C-X-C motif chemokine ligand 1
  • Synonyms
    FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1
  • Links
    NCBI Gene ID: 2919
    neXtProt AC: NX_P09341
    UniProt: P09341

  • Chr Location
    4q13.3; chr4:73869393-73871308 (+)  GRCh38
  • Human Ortholog
    CXCL2, C-X-C motif chemokine ligand 2
  • Synonyms
    CINC-2a, GRO2, GROb, MGSA-b, MIP2, MIP-2a, MIP2A, SCYB2
  • Links
    NCBI Gene ID: 2920
    neXtProt AC: NX_P19875
    UniProt: P19875

  • Chr Location
    4q13.3; chr4:74097040-74099196 (-)  GRCh38
  • Human Ortholog
    CXCL3, C-X-C motif chemokine ligand 3
  • Synonyms
    CINC-2b, GRO3, GROg, MIP-2b, MIP2B, SCYB3
  • Links
    NCBI Gene ID: 2921
    neXtProt AC: NX_P19876
    UniProt: P19876

  • Chr Location
    4q13.3; chr4:74036589-74038807 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    4
  • Radiation induced
    1
  • Spontaneous
    1
  • Transgenic
    1
  • Genomic Mutations
    4 involving Cxcl2
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    14 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    47
  • cDNA Data
    14
  • Literature Summary
    18
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20310 NCBI Gene Model | MGI Sequence Detail 2040 C57BL/6J ±  kb
transcript NM_009140 RefSeq | MGI Sequence Detail 1083 ZRU/MplStud  
polypeptide P10889 UniProt | EBI | MGI Sequence Detail 100 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 1
    cDNA 14
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12243, MGD-MRK-14338, MGI:96991, MGI:98264
References
more
  • Summaries
    All 130
    Developmental Gene Expression 18
    Gene Ontology 12
    Phenotypes 16
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:354145 Lin W, et al., Early infiltrating NKT lymphocytes attenuate bone regeneration through secretion of CXCL2. Sci Adv. 2024 May 17;10(20):eadl6343
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory