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Tnks Gene Detail
Summary
  • Symbol
    Tnks
  • Name
    tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
  • Synonyms
    4930554K12Rik, D130072O21Rik, mTNKS1, Parp5a, TANK1, tankyrase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341087
    NCBI Gene: 21951
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:35296333-35432844 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 21.16 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3143 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341087
 protein coding gene Chr8:35293614-35432844 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033536
 protein coding gene Chr8:33381914-33523690 (-)
A/J MGP_AJ_G0033516
 protein coding gene Chr8:32048265-32183300 (-)
AKR/J MGP_AKRJ_G0033440
 protein coding gene Chr8:33058682-33198919 (-)
BALB/cJ MGP_BALBcJ_G0033512
 protein coding gene Chr8:32167988-32304837 (-)
C3H/HeJ MGP_C3HHeJ_G0033224
 protein coding gene Chr8:33397261-33534250 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034028
 protein coding gene Chr8:34664382-34808271 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030977
 protein coding gene Chr8:29043752-29182733 (-)
CAST/EiJ MGP_CASTEiJ_G0032551
 protein coding gene Chr8:32866115-33009651 (-)
CBA/J MGP_CBAJ_G0033202
 protein coding gene Chr8:35976118-36121439 (-)
DBA/2J MGP_DBA2J_G0033355
 protein coding gene Chr8:32017589-32152685 (-)
FVB/NJ MGP_FVBNJ_G0033300
 protein coding gene Chr8:31686161-31823235 (-)
LP/J MGP_LPJ_G0033445
 protein coding gene Chr8:33349870-33491769 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033342
 protein coding gene Chr8:35482377-35626789 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034047
 protein coding gene Chr8:33154153-33292258 (-)
PWK/PhJ MGP_PWKPhJ_G0032262
 protein coding gene Chr8:31569013-31705126 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032093
 protein coding gene Chr8:32427362-32567672 (-)
WSB/EiJ MGP_WSBEiJ_G0032667
 protein coding gene Chr8:33326170-33470381 (-)



Homology
more
  • Human Ortholog
    TNKS, tankyrase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNKS, tankyrase
  • Synonyms
    ARTD5, PARP-5a, PARP5A, PARPL, pART5, TIN1, TINF1, TNKS1
  • Links
    NCBI Gene ID: 8658
    neXtProt AC: NX_O95271
    UniProt: O95271

  • Chr Location
    8p23.1; chr8:9555912-9782346 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele fail to exhibit any abonormalities. Male mice homozygous for a gene trapped allele exhibit decreased fat pad weight, increased metabolism, hyperinsulinemia, and hypoglycemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    811
  • Tissues
    19
  • cDNA Data
    183
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21951 NCBI Gene Model | MGI Sequence Detail 136512 C57BL/6J ±  kb
    transcript NM_175091 RefSeq | MGI Sequence Detail 6444 C57BL/6  
    polypeptide Q6PFX9 UniProt | EBI | MGI Sequence Detail 1320 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 184
      cDNA 183
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1922501, MGI:2142612, MGI:2142876
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 16
    • Earliest
      J:51381 Zhu L, et al., Chromosomal mapping of the Tankyrase gene in human and mouse. Genomics. 1999;57:320-321
    • Latest
      J:346147 Hou S, et al., PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis. Mol Cell. 2024 Mar 7;84(5):938-954.e8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory