About   Help   FAQ
Tlr1 Gene Detail
Summary
  • Symbol
    Tlr1
  • Name
    toll-like receptor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341295
    NCBI Gene: 21897
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:65082022-65090906 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 33.53 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    355 from dbSNP Build 142
  • Strain Annotations
    15
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341295
 protein coding gene Chr5:65082022-65090945 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029568
 protein coding gene Chr5:64531554-64541912 (-)
A/J MGP_AJ_G0029536
 protein coding gene Chr5:62137021-62146164 (-)
AKR/J MGP_AKRJ_G0029484
 protein coding gene Chr5:64090699-64099166 (-)
BALB/cJ MGP_BALBcJ_G0029545
 protein coding gene Chr5:62824642-62833138 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0029999
 protein coding gene Chr5:67215261-67215880 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027239
 protein coding gene Chr5:58209609-58218451 (-)
CAST/EiJ MGP_CASTEiJ_G0028676
 protein coding gene Chr5:63542485-63551656 (-)
CBA/J MGP_CBAJ_G0029237
 protein coding gene Chr5:69370497-69379622 (-)
DBA/2J MGP_DBA2J_G0029383
 protein coding gene Chr5:62161999-62170861 (-)
FVB/NJ MGP_FVBNJ_G0029343
 protein coding gene Chr5:61342312-61350991 (-)
LP/J MGP_LPJ_G0029469
 protein coding gene Chr5:65025358-65035407 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029371
 protein coding gene Chr5:72276337-72284886 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030032
 protein coding gene Chr5:63780567-63789030 (-)
PWK/PhJ MGP_PWKPhJ_G0028400
 protein coding gene Chr5:61131502-61141630 (-)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TLR1, toll like receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLR1, toll like receptor 1
  • Synonyms
    CD281, rsc786, TIL, TIL. LPRS5
  • Links
    NCBI Gene ID: 7096
    neXtProt AC: NX_Q15399
    UniProt: Q15399

  • Chr Location
    4p14; chr4:38787569-38856817 (-)  GRCh38
Human Diseases
more
  • Diseases
    6 with human TLR1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display decreased macrophage peptoglycan-stimulated IL-6 production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    14
  • cDNA Data
    25
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044827 Ensembl Gene Model | MGI Sequence Detail 8885 C57BL/6J ±  kb
    transcript ENSMUST00000197315 Ensembl | MGI Sequence Detail 3025 Not Applicable  
    polypeptide ENSMUSP00000142500 Ensembl | MGI Sequence Detail 795 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000001151 Toll-like receptor 1
      (term hierarchy)
    • InterPro Domains
      IPR000483 Cysteine-rich flanking region, C-terminal
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
      IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
      IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
      IPR017241 Toll-like receptor
    • GlyGen
      Q9EPQ1 9 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 25
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 5
      Gene Ontology 13
      Phenotypes 56
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory