Tlr6 MGI Mouse Gene Detail - MGI:1341296

Symbol

Tlr6
Name

toll-like receptor 6

Feature Type

protein coding gene
IDs

MGI:1341296
NCBI Gene: 21899
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr5:65109374-65117440 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 33.54 cM
Mapping Data

2 experiments

SNPs within 2kb

326 from dbSNP Build 142
Strain Annotations

17
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1341296	protein coding gene	Chr5:65109373-65128387 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029569	protein coding gene	Chr5:64557978-64566638 (-)
A/J	MGP_AJ_G0029537	protein coding gene	Chr5:62164743-62172820 (-)
AKR/J	MGP_AKRJ_G0029485	protein coding gene	Chr5:64120281-64128868 (-)
BALB/cJ	MGP_BALBcJ_G0029546	protein coding gene	Chr5:62850572-62859610 (-)
C3H/HeJ	MGP_C3HHeJ_G0029269	protein coding gene	Chr5:64477001-64486161 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030000	protein coding gene	Chr5:67237310-67246460 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027240	protein coding gene	Chr5:58229701-58244182 (-)
CAST/EiJ	MGP_CASTEiJ_G0028677	protein coding gene	Chr5:63563683-63579051 (-)
CBA/J	MGP_CBAJ_G0029238	protein coding gene	Chr5:69398510-69408938 (-)
DBA/2J	MGP_DBA2J_G0029384	protein coding gene	Chr5:62182630-62190697 (-)
FVB/NJ	MGP_FVBNJ_G0029344	protein coding gene	Chr5:61369995-61378550 (-)
LP/J	no annotation
NOD/ShiLtJ	MGP_NODShiLtJ_G0029372	protein coding gene	Chr5:72302421-72307295 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030033	protein coding gene	Chr5:63810966-63820632 (-)
PWK/PhJ	MGP_PWKPhJ_G0028401	protein coding gene	Chr5:61157664-61165850 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028235	protein coding gene	Chr5:63118615-63128008 (-)
WSB/EiJ	MGP_WSBEiJ_G0028757	protein coding gene	Chr5:64009502-64017998 (-)

Human Ortholog

TLR6, toll like receptor 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TLR6, toll like receptor 6
Synonyms

CD286
Links

HGNC:16711

NCBI Gene ID: 10333

neXtProt AC: NX_Q9Y2C9

UniProt: Q9Y2C9
Chr Location

4p14; chr4:38822897-38868390 (-) GRCh38

MGI Vertebrate Homology

Tlr6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TLR6
Protein SuperFamily

Toll-like_receptor
Gene Tree

Tlr6

Diseases

5 with human TLR6 associations

				Human Disease	Mouse Models
				aspergillosis IDs aspergillosis DOID:13564 ICD10CM:B44 ICD9CM:117.3 MESH:D001228 NCI:C2886 UMLS_CUI:C0004030
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				infective endocarditis IDs infective endocarditis DOID:0060000
				rhinitis IDs rhinitis DOID:4483 MESH:D012220 NCI:C34986 UMLS_CUI:C0035455
				tuberculosis IDs tuberculosis DOID:399 DOID:10096 DOID:12688 DOID:12691 DOID:415 DOID:9901 DOID:9902 MESH:D014375 UMLS_CUI:C0041295

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 5 alleles in 5 genetic backgrounds
1 phenotype from multigenic genotypes
81 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (ENU)

4
Chemically induced (other)

2
Endonuclease-mediated

1
Radiation induced

1
Spontaneous

1
Targeted

4
Genomic Mutations

4 involving Tlr6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

50 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Inactivation of this gene results in abnormal macrophage function.

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All GO Annotations

61
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

734
Tissues

15
cDNA Data

9
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tlr6

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All Sequences

46
RefSeq

10
UniProt

5
CCDS

CCDS19303.1

Ensembl

ENSMUSG00000051498 (Evidence)
NCBI Gene

21899

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051498	Ensembl Gene Model \| MGI Sequence Detail	8067	C57BL/6J	± kb
transcript	ENSMUST00000239485	Ensembl \| MGI Sequence Detail	2603	Not Applicable
polypeptide	ENSMUSP00000159286	Ensembl \| MGI Sequence Detail	806	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000001157 Toll-like receptor 6

(term hierarchy)
PDB

3A79
InterPro Domains

IPR000483 Cysteine-rich flanking region, C-terminal

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain

IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily

IPR017241 Toll-like receptor
GlyGen

Q9EPW9 10 sites, 2 N-linked glycans (2 sites)

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All nucleic 13

cDNA 10

Primer pair 3

Microarray probesets 3

Summaries

All 136

Developmental Gene Expression 7

Gene Ontology 16

Phenotypes 81
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:325188 Morrissey SM, et al., Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming. Cell Metab. 2021 Oct 5;33(10):2040-2058.e10

TSS for Tlr6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr1491	Chr5:65118672-65118680 (-)	-1,236 bp
Tssr51082	Chr5:65118392-65118407 (-)	-960 bp
Tssr51081	Chr5:65118374-65118388 (-)	-941 bp
Tssr51080	Chr5:65118179-65118194 (-)	-747 bp
Tssr1490	Chr5:65118152-65118172 (-)	-722 bp
Tssr51079	Chr5:65117375-65117412 (-)	46 bp
Tssr51078	Chr5:65116520-65116539 (-)	910 bp
Tssr51077	Chr5:65116460-65116518 (-)	951 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24