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Pbx2 Gene Detail
Summary
  • Symbol
    Pbx2
  • Name
    pre B cell leukemia homeobox 2
  • Synonyms
    G17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341793
    NCBI Gene: 18515
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34811233-34816374 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.17 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341793
 protein coding gene Chr17:34810240-34816374 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023578
 protein coding gene Chr17:34665477-34672031 (+)
A/J MGP_AJ_G0023540
 protein coding gene Chr17:33490332-33494842 (+)
AKR/J MGP_AKRJ_G0023505
 protein coding gene Chr17:33907443-33912292 (+)
BALB/cJ MGP_BALBcJ_G0023544
 protein coding gene Chr17:33638285-33643162 (+)
C3H/HeJ MGP_C3HHeJ_G0023304
 protein coding gene Chr17:34299696-34306650 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023984
 protein coding gene Chr17:35986852-35991851 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021463
 protein coding gene Chr17:31377741-31383846 (+)
CAST/EiJ MGP_CASTEiJ_G0022804
 protein coding gene Chr17:34373529-34378336 (+)
CBA/J MGP_CBAJ_G0023282
 protein coding gene Chr17:37515294-37522485 (+)
DBA/2J MGP_DBA2J_G0023410
 protein coding gene Chr17:32775618-32785648 (+)
FVB/NJ MGP_FVBNJ_G0023377
 protein coding gene Chr17:32682178-32688396 (+)
LP/J MGP_LPJ_G0023488
 protein coding gene Chr17:34942178-34947143 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023400
 protein coding gene Chr17:36405344-36410733 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024027
 protein coding gene Chr17:34212647-34217452 (+)
PWK/PhJ MGP_PWKPhJ_G0022552
 protein coding gene Chr17:31708217-31714396 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022369
 protein coding gene Chr17:32202276-32207087 (+)
WSB/EiJ MGP_WSBEiJ_G0022865
 protein coding gene Chr17:34303547-34309607 (+)



Homology
more
  • Human Ortholog
    PBX2, PBX homeobox 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PBX2, PBX homeobox 2
  • Synonyms
    G17, HOX12, PBX2MHC
  • Links
    NCBI Gene ID: 5089
    neXtProt AC: NX_P40425
    UniProt: P40425

  • Chr Location
    6p21.32; chr6:32184733-32190202 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    21 phenotypes from multigenic genotypes
    26 phenotype references
Homozygous null mice are healthy and fertile with no apparent abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    864
  • Tissues
    145
  • cDNA Data
    71
  • Literature Summary
    44
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18515 NCBI Gene Model | MGI Sequence Detail 5142 C57BL/6J ±  kb
transcript NM_017463 RefSeq | MGI Sequence Detail 3072 C57BL/6  
polypeptide O35984 UniProt | EBI | MGI Sequence Detail 430 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 78
    Genomic 1
    cDNA 72
    Primer pair 3
    Other 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147002
References
more
  • Summaries
    All 85
    Developmental Gene Expression 44
    Gene Ontology 8
    Phenotypes 26
  • Earliest
    J:2599 Monica K, et al., PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. Mol Cell Biol. 1991 Dec;11(12):6149-57
  • Latest
    J:349843 Ning Y, et al., Transcription factor PBX4 regulates limb development and haematopoiesis in mice. Cell Prolif. 2024 May;57(5):e13580
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory