Mark3 MGI Mouse Gene Detail - MGI:1341865 - MAP/microtubule affinity regulating kinase 3

Symbol

Mark3
Name

MAP/microtubule affinity regulating kinase 3
Synonyms

1600015G02Rik, A430080F22Rik, C-TAK1, ETK-1, mKIAA1860

Feature Type

protein coding gene
IDs

MGI:1341865
NCBI Gene: 17169
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:111540957-111622655 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 61.05 cM, cytoband F2
Mapping Data

2 experiments

SNPs within 2kb

1689 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1341865	protein coding gene	Chr12:111540929-111622661 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020136	protein coding gene	Chr12:113973576-114056119 (+)
A/J	MGP_AJ_G0020092	protein coding gene	Chr12:109589710-109678683 (+)
AKR/J	MGP_AKRJ_G0020067	protein coding gene	Chr12:112727626-112814639 (+)
BALB/cJ	MGP_BALBcJ_G0020077	protein coding gene	Chr12:110018074-110102171 (+)
C3H/HeJ	MGP_C3HHeJ_G0019879	protein coding gene	Chr12:113229409-113315993 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020522	protein coding gene	Chr12:117508930-117598668 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018135	protein coding gene	Chr12:106031084-106120832 (+)
CAST/EiJ	MGP_CASTEiJ_G0019420	protein coding gene	Chr12:108069607-108154982 (+)
CBA/J	MGP_CBAJ_G0019846	protein coding gene	Chr12:121977517-122068594 (+)
DBA/2J	MGP_DBA2J_G0019963	protein coding gene	Chr12:109070722-109154021 (+)
FVB/NJ	MGP_FVBNJ_G0019948	protein coding gene	Chr12:107871075-107954909 (+)
LP/J	MGP_LPJ_G0020038	protein coding gene	Chr12:113795739-113883187 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019986	protein coding gene	Chr12:125106846-125195145 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020551	protein coding gene	Chr12:112242018-112336047 (+)
PWK/PhJ	MGP_PWKPhJ_G0019181	protein coding gene	Chr12:103712075-103795277 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018984	protein coding gene	Chr12:106406052-106503581 (+)
WSB/EiJ	MGP_WSBEiJ_G0019479	protein coding gene	Chr12:113159343-113246919 (+)

Human Ortholog

MARK3, microtubule affinity regulating kinase 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MARK3, microtubule affinity regulating kinase 3
Synonyms

CTAK1, KP78, Par-1a, PAR1A, VIPB
Links

HGNC:6897

NCBI Gene ID: 4140

neXtProt AC: NX_P27448

UniProt: P27448
Chr Location

14q32.32-q32.33; chr14:103385377-103503831 (+) GRCh38

MGI Vertebrate Homology

Mark3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MARK3
Gene Tree

Mark3

Diseases

1 with human MARK3 associations

				Human Disease	Mouse Models
				visual impairment and progressive phthisis bulbi IDs visual impairment and progressive phthisis bulbi DOID:0070356 MESH:D005128 OMIM:618283

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

16 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

59
Endonuclease-mediated

2
Gene trapped

50
Spontaneous

1
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

71 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous disruption of this gene results in decreased body weight, increased energy expenditure, reduced adiposity, and protection from high-fat diet induced obesity. On a high-fat diet, mice show resistance to hepatic steatosis, improved glucose tolerance, and decreased insulin levels.

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All GO Annotations

33
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

726
Tissues

17
cDNA Data

16
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mark3

ZFIN mark3a

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All Sequences

114
RefSeq

43
UniProt

7
CCDS

CCDS26181.1, CCDS26182.1, CCDS88407.1

Ensembl

ENSMUSG00000007411 (Evidence)
NCBI Gene

17169

			Length	Strain/Species	Flank
genomic	ENSMUSG00000007411	Ensembl Gene Model \| MGI Sequence Detail	81699	C57BL/6J	± kb
transcript	ENSMUST00000221753	Ensembl \| MGI Sequence Detail	2394	Not Applicable
polypeptide	ENSMUSP00000152727	Ensembl \| MGI Sequence Detail	797	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000010188 MAP/microtubule affinity-regulating kinase 3

(term hierarchy)
PDB

1UL7, 1V5S
EC

2.7.11.1
InterPro Domains

IPR028375 KA1 domain/Ssp2, C-terminal

IPR001772 Kinase associated domain 1 (KA1)

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR049508 Serine/threonine-protein kinase MARK 1-4, catalytic domain

IPR015940 Ubiquitin-associated domain
GlyGen

Q03141 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 20

cDNA 19

Primer pair 1

Microarray probesets 3

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MGI:1913749, MGI:2441800

Summaries

All 59

Developmental Gene Expression 7

Gene Ontology 9

Phenotypes 17
Earliest

J:31015 Hanks SK, et al., The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science. 1988 Jul 1;241(4861):42-52
Latest

J:305797 Zhang Q, et al., Genomic variants within chromosome 14q32.32 regulate bone mass through MARK3 signaling in osteoblasts. J Clin Invest. 2021 Apr 1;131(7)

TSS for Mark3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115333	Chr12:111540925-111540976 (+)	-6 bp
Tssr115334	Chr12:111550058-111550063 (+)	9,104 bp
Tssr115335	Chr12:111550074-111550088 (+)	9,124 bp
Tssr115336	Chr12:111550096-111550099 (+)	9,141 bp
Tssr115337	Chr12:111559083-111559106 (+)	18,138 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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