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Mmp24 Gene Detail
Summary
  • Symbol
    Mmp24
  • Name
    matrix metallopeptidase 24
  • Synonyms
    Membrane type 5-MMP, MT5-MMP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341867
    NCBI Gene: 17391
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:155617262-155660286 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 77.26 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1111 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341867
 protein coding gene Chr2:155617262-155660286 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026743
 protein coding gene Chr2:160619719-160667069 (+)
A/J MGP_AJ_G0026709
 protein coding gene Chr2:154238329-154282785 (+)
AKR/J MGP_AKRJ_G0026680
 protein coding gene Chr2:158727387-158770403 (+)
BALB/cJ MGP_BALBcJ_G0026718
 protein coding gene Chr2:154531926-154573000 (+)
C3H/HeJ MGP_C3HHeJ_G0026461
 protein coding gene Chr2:159076396-159120937 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027167
 protein coding gene Chr2:165331218-165375162 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024537
 protein coding gene Chr2:147734761-147777895 (+)
CAST/EiJ MGP_CASTEiJ_G0025922
 protein coding gene Chr2:159393488-159439038 (+)
CBA/J MGP_CBAJ_G0026438
 protein coding gene Chr2:171330779-171376310 (+)
DBA/2J MGP_DBA2J_G0026575
 protein coding gene Chr2:153418621-153461524 (+)
FVB/NJ MGP_FVBNJ_G0026542
 protein coding gene Chr2:151794406-151836954 (+)
LP/J MGP_LPJ_G0026680
 protein coding gene Chr2:160759610-160805002 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026563
 protein coding gene Chr2:175317853-175361432 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027223
 protein coding gene Chr2:158590178-158634155 (+)
PWK/PhJ MGP_PWKPhJ_G0025656
 protein coding gene Chr2:152914525-152958440 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025459
 protein coding gene Chr2:157530871-157579598 (+)
WSB/EiJ MGP_WSBEiJ_G0025992
 protein coding gene Chr2:159484625-159527041 (+)



Homology
more
  • Human Ortholog
    MMP24, matrix metallopeptidase 24
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MMP24, matrix metallopeptidase 24
  • Synonyms
    MMP-24, MMP25, MT5-MMP, MT5MMP, MT-MMP 5, MT-MMP5, MTMMP5
  • Links
    NCBI Gene ID: 10893
    neXtProt AC: NX_Q9Y5R2
    UniProt: Q9Y5R2

  • Chr Location
    20q11.22; chr20:35226690-35276998 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene fail to develop neuropathic pain after peripheral nerve injury. They also experience reduced stress and enhanced mechanical coordination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    857
  • Tissues
    63
  • cDNA Data
    15
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17391 NCBI Gene Model | MGI Sequence Detail 43025 C57BL/6J ±  kb
    transcript NM_010808 RefSeq | MGI Sequence Detail 4306 ZRU/MplStud  
    polypeptide Q9R0S2 UniProt | EBI | MGI Sequence Detail 618 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 16
      Primer pair 2
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2139209
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:50709 Pei D, Identification and characterization of the fifth membrane-type matrix metalloproteinase MT5-MMP. J Biol Chem. 1999 Mar 26;274(13):8925-32
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory