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Stk11 Gene Detail
Summary
  • Symbol
    Stk11
  • Name
    serine/threonine kinase 11
  • Synonyms
    Lkb1, Par-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341870
    NCBI Gene: 20869
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:79951637-79966516 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    246 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341870
 protein coding gene Chr10:79951602-79966516 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017482
 protein coding gene Chr10:80701021-80717590 (+)
A/J MGP_AJ_G0017460
 protein coding gene Chr10:77877487-77894089 (+)
AKR/J MGP_AKRJ_G0017421
 protein coding gene Chr10:80002816-80018426 (+)
BALB/cJ MGP_BALBcJ_G0017422
 protein coding gene Chr10:78101147-78116038 (+)
C3H/HeJ MGP_C3HHeJ_G0017245
 protein coding gene Chr10:80104448-80119297 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017876
 protein coding gene Chr10:83483691-83498493 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015564
 protein coding gene Chr10:74102740-74119109 (+)
CAST/EiJ MGP_CASTEiJ_G0016812
 protein coding gene Chr10:80301953-80319155 (+)
CBA/J MGP_CBAJ_G0017217
 protein coding gene Chr10:86722950-86737785 (+)
DBA/2J MGP_DBA2J_G0017323
 protein coding gene Chr10:77092064-77107342 (+)
FVB/NJ MGP_FVBNJ_G0017317
 protein coding gene Chr10:76275690-76291309 (+)
LP/J MGP_LPJ_G0017394
 protein coding gene Chr10:81175866-81191194 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017343
 protein coding gene Chr10:88671947-88688502 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017917
 protein coding gene Chr10:79983993-80001062 (+)
PWK/PhJ MGP_PWKPhJ_G0016593
 protein coding gene Chr10:76961522-76979296 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016382
 protein coding gene Chr10:78965437-78982187 (+)
WSB/EiJ MGP_WSBEiJ_G0016872
 protein coding gene Chr10:80013658-80029753 (+)



Homology
more
  • Human Ortholog
    STK11, serine/threonine kinase 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STK11, serine/threonine kinase 11
  • Synonyms
    hLKB1, LKB1, PJS
  • Links
    NCBI Gene ID: 6794
    neXtProt AC: NX_Q15831
    UniProt: Q15831

  • Chr Location
    19p13.3; chr19:1177558-1228431 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Stk11 mouse models; 5 with human STK11 associations

Human Disease Mouse Models
      
IDs
 View 9 models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    7 with disease annotations
  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    168 phenotypes from 12 alleles in 25 genetic backgrounds
    51 phenotypes from multigenic genotypes
    6 images
    266 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted heterozygous mutants with one inactivated allele develop benign gastrointestinal polyps. Homozygous null mutant are embryonic lethal. Homozygotes for a hypomorphic allele survive and apparently normal, but male mice are infertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    157
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    43
  • cDNA Data
    21
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003068 Ensembl Gene Model | MGI Sequence Detail 14880 C57BL/6J ±  kb
    transcript ENSMUST00000003152 Ensembl | MGI Sequence Detail 2566 Not Applicable  
    polypeptide ENSMUSP00000003152 Ensembl | MGI Sequence Detail 436 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 1
      cDNA 21
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143460, MGI:2143959
    References
    more
    • Summaries
      All 370
      Developmental Gene Expression 18
      Diseases 12
      Gene Ontology 34
      Phenotypes 266
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:351288 Lan T, et al., Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer. Nat Commun. 2024 Jul 12;15(1):5857
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory