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Tjp2 Gene Detail
Summary
  • Symbol
    Tjp2
  • Name
    tight junction protein 2
  • Synonyms
    ZO-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341872
    NCBI Gene: 21873
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:24071869-24202394 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 19.17 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4769 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341872
 protein coding gene Chr19:24071860-24202492 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024992
 protein coding gene Chr19:22290421-22374925 (-)
A/J MGP_AJ_G0024969
 protein coding gene Chr19:21071621-21119842 (-)
AKR/J MGP_AKRJ_G0024939
 protein coding gene Chr19:21876383-21924625 (-)
BALB/cJ MGP_BALBcJ_G0024968
 protein coding gene Chr19:21110074-21252134 (-)
C3H/HeJ MGP_C3HHeJ_G0024725
 protein coding gene Chr19:21826506-21875917 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025409
 protein coding gene Chr19:22994328-23141958 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022828
 protein coding gene Chr19:21248439-21379421 (-)
CAST/EiJ MGP_CASTEiJ_G0024194
 protein coding gene Chr19:21574535-21661930 (-)
CBA/J MGP_CBAJ_G0024703
 protein coding gene Chr19:24012492-24067424 (-)
DBA/2J MGP_DBA2J_G0024835
 protein coding gene Chr19:21075888-21124558 (-)
FVB/NJ MGP_FVBNJ_G0024796
 protein coding gene Chr19:20939873-21077495 (-)
LP/J MGP_LPJ_G0024919
 protein coding gene Chr19:22242786-22324871 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024823
 protein coding gene Chr19:24043976-24187566 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025464
 protein coding gene Chr19:21876537-22014568 (-)
PWK/PhJ MGP_PWKPhJ_G0023942
 protein coding gene Chr19:20677427-20758041 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023747
 protein coding gene Chr19:21101322-21191699 (-)
WSB/EiJ MGP_WSBEiJ_G0024261
 protein coding gene Chr19:21895967-21978546 (-)



Homology
more
  • Human Ortholog
    TJP2, tight junction protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TJP2, tight junction protein 2
  • Synonyms
    C9DUPq21.11, DFNA51, DUP9q21.11, FHCA1, PFIC4, X104, ZO2
  • Links
    NCBI Gene ID: 9414
    neXtProt AC: NX_Q9UDY2
    UniProt: Q9UDY2

  • Chr Location
    9q21.11; chr9:69121264-69274615 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TJP2 associations

Human Disease Mouse Models
      
IDs
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality shortly after implantation due to arrest in early gastrulation. Structure and permeability barrier of the apical junctional complex are altered in cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    852
  • Tissues
    101
  • cDNA Data
    165
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024812 Ensembl Gene Model | MGI Sequence Detail 130526 C57BL/6J ±  kb
    transcript ENSMUST00000233027 Ensembl | MGI Sequence Detail 4668 Not Applicable  
    polypeptide ENSMUSP00000156605 Ensembl | MGI Sequence Detail 1190 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 170
      cDNA 166
      Primer pair 4

      Microarray probesets 5
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 30
      Diseases 1
      Gene Ontology 14
      Phenotypes 16
    • Earliest
      J:53203 Itoh M, et al., Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin. J Biol Chem. 1999 Feb 26;274(9):5981-6
    • Latest
      J:351038 Wu X, et al., TEAD4 regulates KRT8 and YAP in preimplantation embryos in mice but not in cattle. Reproduction. 2024 Mar 1;167(3):e230322
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory