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Gfra4 Gene Detail
Summary
  • Symbol
    Gfra4
  • Name
    glial cell line derived neurotrophic factor family receptor alpha 4
  • Synonyms
    G630015H18Rik, GFR alpha-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341873
    NCBI Gene: 14588
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr2:130881552-130885008 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 63.26 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341873
 protein coding gene Chr2:130881552-130885008 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026518
 protein coding gene Chr2:134541071-134544527 (-)
A/J MGP_AJ_G0026482
 protein coding gene Chr2:129086697-129090153 (-)
AKR/J MGP_AKRJ_G0026457
 protein coding gene Chr2:132820982-132824438 (-)
BALB/cJ MGP_BALBcJ_G0026494
 protein coding gene Chr2:129474688-129478139 (-)
C3H/HeJ MGP_C3HHeJ_G0026237
 protein coding gene Chr2:133247900-133251356 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026939
 protein coding gene Chr2:138683671-138687127 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024316
 protein coding gene Chr2:123825652-123829128 (-)
CAST/EiJ MGP_CASTEiJ_G0025698
 protein coding gene Chr2:133522124-133525581 (-)
CBA/J MGP_CBAJ_G0026217
 protein coding gene Chr2:143836182-143839638 (-)
DBA/2J MGP_DBA2J_G0026351
 protein coding gene Chr2:128472611-128476067 (-)
FVB/NJ MGP_FVBNJ_G0026315
 protein coding gene Chr2:127107655-127111111 (-)
LP/J MGP_LPJ_G0026456
 protein coding gene Chr2:134781773-134785229 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026335
 protein coding gene Chr2:147657284-147660740 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026994
 protein coding gene Chr2:132771585-132775041 (-)
PWK/PhJ MGP_PWKPhJ_G0025434
 protein coding gene Chr2:128041736-128045183 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025236
 protein coding gene Chr2:131922778-131926212 (-)
WSB/EiJ MGP_WSBEiJ_G0025772
 protein coding gene Chr2:133696262-133699718 (-)



Homology
more
  • Human Ortholog
    GFRA4, GDNF family receptor alpha 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GFRA4, GDNF family receptor alpha 4
  • Links
    NCBI Gene ID: 64096
    neXtProt AC: NX_Q9GZZ7
    UniProt: Q9GZZ7

  • Chr Location
    20p13; chr20:3659248-3663399 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations are mice were viable, fertile, showed no overt anatomical defects. Thyroid tissue calcitonin content was reduced in null homozygotes and rate of bone formation was enhanced when in 129/B6 hybrid background strain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1005
  • Tissues
    120
  • cDNA Data
    21
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14588 NCBI Gene Model | MGI Sequence Detail 3457 C57BL/6J ±  kb
    transcript NM_020014 RefSeq | MGI Sequence Detail 1457 Not Specified  
    polypeptide Q9JJT2 UniProt | EBI | MGI Sequence Detail 260 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 1
      cDNA 22
      Primer pair 10
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139291
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:277959 Catela C, et al., Hox Proteins Coordinate Motor Neuron Differentiation and Connectivity Programs through Ret/Gfralpha Genes. Cell Rep. 2016 Mar 1;14(8):1901-15
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory