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Aicda Gene Detail
Summary
  • Symbol
    Aicda
  • Name
    activation-induced cytidine deaminase
  • Synonyms
    Aid
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342279
    NCBI Gene: 11628
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:122530768-122541139 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 57.65 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    418 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342279
 protein coding gene Chr6:122530760-122541139 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031228
 protein coding gene Chr6:125646534-125658948 (+)
A/J MGP_AJ_G0031197
 protein coding gene Chr6:120893441-120903828 (+)
AKR/J MGP_AKRJ_G0031126
 protein coding gene Chr6:124236814-124247175 (+)
BALB/cJ MGP_BALBcJ_G0031206
 protein coding gene Chr6:120581233-120591642 (+)
C3H/HeJ MGP_C3HHeJ_G0030925
 protein coding gene Chr6:124183352-124194359 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031665
 protein coding gene Chr6:128941073-128953187 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028824
 protein coding gene Chr6:117501796-117512418 (+)
CAST/EiJ MGP_CASTEiJ_G0030315
 protein coding gene Chr6:124451092-124461464 (+)
CBA/J MGP_CBAJ_G0030889
 protein coding gene Chr6:133972384-133989804 (+)
DBA/2J MGP_DBA2J_G0031045
 protein coding gene Chr6:119807194-119817891 (+)
FVB/NJ MGP_FVBNJ_G0030997
 protein coding gene Chr6:118757476-118768686 (+)
LP/J MGP_LPJ_G0031125
 protein coding gene Chr6:125798109-125810872 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031032
 protein coding gene Chr6:137940018-137951281 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031695
 protein coding gene Chr6:124130398-124140908 (+)
PWK/PhJ MGP_PWKPhJ_G0030029
 protein coding gene Chr6:118641580-118652122 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029856
 protein coding gene Chr6:122253213-122266472 (+)
WSB/EiJ MGP_WSBEiJ_G0030397
 protein coding gene Chr6:124432278-124443024 (+)



Homology
more
  • Human Ortholog
    AICDA, activation induced cytidine deaminase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AICDA, activation induced cytidine deaminase
  • Synonyms
    AID, ARP2, CDA2, HEL-S-284, HIGM2
  • Links
    NCBI Gene ID: 57379
    neXtProt AC: NX_Q9GZX7
    UniProt: Q9GZX7

  • Chr Location
    12p13.31; chr12:8602155-8613242 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Aicda mouse models; 2 with human AICDA associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 13 alleles in 12 genetic backgrounds
    24 phenotypes from multigenic genotypes
    326 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in elevated IgM levels and impairment of B cell class switching.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    938
  • Tissues
    205
  • cDNA Data
    7
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11628 NCBI Gene Model | MGI Sequence Detail 10372 C57BL/6J ±  kb
    transcript NM_009645 RefSeq | MGI Sequence Detail 2413 Not Specified  
    polypeptide Q9WVE0 UniProt | EBI | MGI Sequence Detail 198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 8
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 435
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 15
      Phenotypes 326
    • Earliest
      J:55852 Muramatsu M, et al., Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem. 1999 Jun 25;274(26):18470-6
    • Latest
      J:358941 Zhu X, et al., The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness. Nat Commun. 2024 Nov 23;15(1):10163
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory