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Rlim Gene Detail
Summary
  • Symbol
    Rlim
  • Name
    ring finger protein, LIM domain interacting
  • Synonyms
    Ha1r, Rlim1, Rnf12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342291
    NCBI Gene: 19820
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:103000770-103024886 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 46.42 cM, cytoband D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    455 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342291
 protein coding gene ChrX:103000769-103024890 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035988
 protein coding gene ChrX:100648102-100671785 (-)
A/J MGP_AJ_G0035969
 protein coding gene ChrX:100544388-100571023 (-)
AKR/J MGP_AKRJ_G0035887
 protein coding gene ChrX:103623644-103647664 (-)
BALB/cJ MGP_BALBcJ_G0035959
 protein coding gene ChrX:99342815-99367310 (-)
C3H/HeJ MGP_C3HHeJ_G0035665
 protein coding gene ChrX:101101318-101129468 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036485
 protein coding gene ChrX:103598390-103623035 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033313
 protein coding gene ChrX:98180882-98184302 (-)
CAST/EiJ MGP_CASTEiJ_G0034951
 protein coding gene ChrX:85361711-85385888 (-)
CBA/J MGP_CBAJ_G0035640
 protein coding gene ChrX:106810924-106837095 (-)
DBA/2J MGP_DBA2J_G0035794
 protein coding gene ChrX:99790935-99815104 (-)
FVB/NJ MGP_FVBNJ_G0035735
 protein coding gene ChrX:99097753-99121246 (-)
LP/J MGP_LPJ_G0035887
 protein coding gene ChrX:101642022-101666101 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035767
 protein coding gene ChrX:111466520-111493092 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036511
 protein coding gene ChrX:100324090-100351433 (-)
PWK/PhJ MGP_PWKPhJ_G0034649
 protein coding gene ChrX:82936986-82961008 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034477
 protein coding gene ChrX:86074887-86098556 (-)
WSB/EiJ MGP_WSBEiJ_G0035091
 protein coding gene ChrX:99049344-99082093 (-)



Homology
more
  • Human Ortholog
    RLIM, ring finger protein, LIM domain interacting
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RLIM, ring finger protein, LIM domain interacting
  • Synonyms
    MRX61, NY-REN-43, RNF12, TOKAS
  • Links
    NCBI Gene ID: 51132
    neXtProt AC: NX_Q9NVW2
    UniProt: Q9NVW2

  • Chr Location
    Xq13.2; chrX:74582976-74614624 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RLIM associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 4 alleles in 3 genetic backgrounds
    1 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-out allele exhibit female-specific embryonic lethality when the allele is inherited maternally due to disruption in X-inactivation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    42
  • cDNA Data
    23
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19820 NCBI Gene Model | MGI Sequence Detail 24117 C57BL/6J ±  kb
    transcript NM_001425962 RefSeq | MGI Sequence Detail 8128 C57BL/6  
    polypeptide Q9WTV7 UniProt | EBI | MGI Sequence Detail 600 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 2
      cDNA 23
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1353615, MGI:2147943, MGI:2148028
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 18
      Gene Ontology 12
      Phenotypes 22
    • Earliest
      J:56497 Bach I, et al., RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat Genet. 1999 Aug;22(4):394-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory