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Hspa4 Gene Detail
Summary
  • Symbol
    Hspa4
  • Name
    heat shock protein 4
  • Synonyms
    70kDa, APG-2, Hsp110, Hsp70RY
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342292
    NCBI Gene: 15525
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:53150641-53191284 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 31.91 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    721 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342292
 protein coding gene Chr11:53150641-53191306 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018287
 protein coding gene Chr11:52622737-52672581 (-)
A/J MGP_AJ_G0018256
 protein coding gene Chr11:50659734-50700003 (-)
AKR/J MGP_AKRJ_G0018226
 protein coding gene Chr11:52303313-52344843 (-)
BALB/cJ MGP_BALBcJ_G0018227
 protein coding gene Chr11:51011636-51052642 (-)
C3H/HeJ MGP_C3HHeJ_G0018038
 protein coding gene Chr11:52269592-52316887 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018679
 protein coding gene Chr11:54214297-54259894 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016329
 protein coding gene Chr11:48186799-48229252 (-)
CAST/EiJ MGP_CASTEiJ_G0017603
 protein coding gene Chr11:52311894-52359291 (-)
CBA/J MGP_CBAJ_G0018013
 protein coding gene Chr11:56767236-56817860 (-)
DBA/2J MGP_DBA2J_G0018123
 protein coding gene Chr11:50405057-50445632 (-)
FVB/NJ MGP_FVBNJ_G0018115
 protein coding gene Chr11:50044249-50086683 (-)
LP/J MGP_LPJ_G0018197
 protein coding gene Chr11:53065778-53110867 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018139
 protein coding gene Chr11:58086180-58146121 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018721
 protein coding gene Chr11:52338286-52383889 (-)
PWK/PhJ MGP_PWKPhJ_G0017378
 protein coding gene Chr11:50911640-50954340 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017173
 protein coding gene Chr11:52145109-52186161 (-)
WSB/EiJ MGP_WSBEiJ_G0017650
 protein coding gene Chr11:51968915-52011833 (-)



Homology
more
  • Human Ortholog
    HSPA4, heat shock protein family A (Hsp70) member 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSPA4, heat shock protein family A (Hsp70) member 4
  • Synonyms
    APG-2, HEL-S-5a, HS24/P52, hsp70, hsp70RY, HSPH2, RY
  • Links
    NCBI Gene ID: 3308
    neXtProt AC: NX_P34932
    UniProt: P34932

  • Chr Location
    5q31.1; chr5:133052013-133106449 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HSPA4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit age-dependent neurofibrillary tangles and tau deposits, impaired contextual conditioning, and impaired bar grasping.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    17
  • cDNA Data
    25
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020361 Ensembl Gene Model | MGI Sequence Detail 40644 C57BL/6J ±  kb
    transcript ENSMUST00000020630 Ensembl | MGI Sequence Detail 4618 Not Applicable  
    polypeptide ENSMUSP00000020630 Ensembl | MGI Sequence Detail 842 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000003414 heat shock 70 kDa protein 4
      (term hierarchy)
    • InterPro Domains
      IPR043129 ATPase, nucleotide binding domain
      IPR018181 Heat shock protein 70, conserved site
      IPR013126 Heat shock protein 70 family
      IPR050451 Heat Shock Protein 70 (HSP70)
      IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
      IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
      IPR042052 HSPA4, nucleotide-binding domain
    • GlyGen
      Q61316 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 2
      cDNA 29

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1096373, MGI:2144116
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory