About   Help   FAQ
Ppef2 Gene Detail
Summary
  • Symbol
    Ppef2
  • Name
    protein phosphatase, EF hand calcium-binding domain 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342304
    NCBI Gene: 19023
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:92374538-92404137 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 46.28 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    894 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342304
 protein coding gene Chr5:92374109-92404759 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029745
 protein coding gene Chr5:93396061-93430428 (-)
A/J MGP_AJ_G0029711
 protein coding gene Chr5:89691355-89721511 (-)
AKR/J MGP_AKRJ_G0029657
 protein coding gene Chr5:92623772-92655723 (-)
BALB/cJ MGP_BALBcJ_G0029721
 protein coding gene Chr5:90575024-90604696 (-)
C3H/HeJ MGP_C3HHeJ_G0029444
 protein coding gene Chr5:93028643-93062463 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030175
 protein coding gene Chr5:97103643-97145282 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027411
 protein coding gene Chr5:85337466-85369942 (-)
CAST/EiJ MGP_CASTEiJ_G0028854
 protein coding gene Chr5:92405193-92435127 (-)
CBA/J MGP_CBAJ_G0029414
 protein coding gene Chr5:100462174-100509757 (-)
DBA/2J MGP_DBA2J_G0029558
 protein coding gene Chr5:89735567-89768899 (-)
FVB/NJ MGP_FVBNJ_G0029517
 protein coding gene Chr5:88583632-88613736 (-)
LP/J MGP_LPJ_G0029646
 protein coding gene Chr5:93767824-93801528 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029546
 protein coding gene Chr5:105391438-105424675 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030209
 protein coding gene Chr5:92155619-92187608 (-)
PWK/PhJ MGP_PWKPhJ_G0028573
 protein coding gene Chr5:88801405-88831719 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028408
 protein coding gene Chr5:91522122-91551522 (-)
WSB/EiJ MGP_WSBEiJ_G0028933
 protein coding gene Chr5:92614331-92645433 (-)



Homology
more
  • Human Ortholog
    PPEF2, protein phosphatase with EF-hand domain 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPEF2, protein phosphatase with EF-hand domain 2
  • Synonyms
    PPP7CB
  • Links
    NCBI Gene ID: 5470
    neXtProt AC: NX_O14830
    UniProt: O14830

  • Chr Location
    4q21.1; chr4:75859864-75902571 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    12 phenotype references
Homozygotes for a targeted null mutation appear to be phenotypically normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    11
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029410 Ensembl Gene Model | MGI Sequence Detail 29600 C57BL/6J ±  kb
transcript ENSMUST00000201130 Ensembl | MGI Sequence Detail 2878 Not Applicable  
polypeptide ENSMUSP00000144157 Ensembl | MGI Sequence Detail 757 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:273146 Zwick M, et al., Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8(+) Dendritic Cells. Front Immunol. 2019;10:222
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory