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Ikzf1 Gene Detail
Summary
  • Symbol
    Ikzf1
  • Name
    IKAROS family zinc finger 1
  • Synonyms
    5832432G11Rik, Ikaros, LyF-1, Zfpn1a1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342540
    NCBI Gene: 22778
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:11634980-11722926 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 7.02 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2330 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342540
 protein coding gene Chr11:11634970-11722930 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018045
 protein coding gene Chr11:8972697-9065587 (+)
A/J MGP_AJ_G0018018
 protein coding gene Chr11:8658286-8748215 (+)
AKR/J MGP_AKRJ_G0017982
 protein coding gene Chr11:9026632-9115976 (+)
BALB/cJ MGP_BALBcJ_G0017986
 protein coding gene Chr11:8680144-8769714 (+)
C3H/HeJ MGP_C3HHeJ_G0017799
 protein coding gene Chr11:8926218-9016947 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018438
 protein coding gene Chr11:9275692-9373430 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016096
 protein coding gene Chr11:8201342-8290450 (+)
CAST/EiJ MGP_CASTEiJ_G0017361
 protein coding gene Chr11:8930270-9026820 (+)
CBA/J MGP_CBAJ_G0017774
 protein coding gene Chr11:9952469-10046366 (+)
DBA/2J MGP_DBA2J_G0017884
 protein coding gene Chr11:8593092-8681591 (+)
FVB/NJ MGP_FVBNJ_G0017876
 protein coding gene Chr11:8502559-8592282 (+)
LP/J MGP_LPJ_G0017955
 protein coding gene Chr11:9081677-9170878 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017902
 protein coding gene Chr11:9667747-9772707 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018479
 protein coding gene Chr11:9042195-9136944 (+)
PWK/PhJ MGP_PWKPhJ_G0017141
 protein coding gene Chr11:8623937-8716563 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016938
 protein coding gene Chr11:8887573-8980929 (+)
WSB/EiJ MGP_WSBEiJ_G0017415
 protein coding gene Chr11:8806352-8899248 (+)



Homology
more
  • Human Ortholog
    IKZF1, IKAROS family zinc finger 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IKZF1, IKAROS family zinc finger 1
  • Synonyms
    CVID13, Hs.54452, IK1, IKAROS, LyF-1, LYF1, PPP1R92, PRO0758, ZNFN1A1
  • Links
    NCBI Gene ID: 10320
    neXtProt AC: NX_Q13422
    UniProt: Q13422

  • Chr Location
    7p12.2; chr7:50303455-50405101 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human IKZF1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    128 phenotypes from 11 alleles in 15 genetic backgrounds
    21 phenotypes from multigenic genotypes
    100 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants have a variety of T, B, and hematopoeitic cell maturation defects. Heterozygotes for one allele exhibit dominant negative effects and mice develop lymphoproliferative disorders.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1010
  • Tissues
    187
  • cDNA Data
    70
  • Literature Summary
    47
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018654 Ensembl Gene Model | MGI Sequence Detail 87947 C57BL/6J ±  kb
    transcript ENSMUST00000065433 Ensembl | MGI Sequence Detail 4697 Not Applicable  
    polypeptide ENSMUSP00000067372 Ensembl | MGI Sequence Detail 535 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      Genomic 1
      cDNA 71
      Primer pair 8
      Other 4

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11345, MGI:2442667, MGI:96535
    References
    more
    • Summaries
      All 226
      Developmental Gene Expression 47
      Diseases 1
      Gene Ontology 23
      Phenotypes 100
    • Earliest
      J:12906 Georgopoulos K, et al., Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. Science. 1992 Oct 30;258(5083):808-12
    • Latest
      J:353865 Ichiyama K, et al., Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity. Immunity. 2024 Jul 30;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory