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Ikzf3 Gene Detail
Summary
  • Symbol
    Ikzf3
  • Name
    IKAROS family zinc finger 3
  • Synonyms
    5830411O07Rik, Aiolos, Zfpn1a3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342542
    NCBI Gene: 22780
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98355728-98436857 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 61.75 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2192 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342542
 protein coding gene Chr11:98355436-98437157 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019062
 protein coding gene Chr11:101015207-101105886 (-)
A/J MGP_AJ_G0019030
 protein coding gene Chr11:96811468-96894057 (-)
AKR/J MGP_AKRJ_G0019000
 protein coding gene Chr11:99811862-99896781 (-)
BALB/cJ MGP_BALBcJ_G0019003
 protein coding gene Chr11:97305414-97388290 (-)
C3H/HeJ MGP_C3HHeJ_G0018817
 protein coding gene Chr11:99944736-100033363 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019456
 protein coding gene Chr11:104099537-104191651 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017087
 protein coding gene Chr11:94251672-94333783 (-)
CAST/EiJ MGP_CASTEiJ_G0018371
 protein coding gene Chr11:100832408-100918838 (-)
CBA/J MGP_CBAJ_G0018788
 protein coding gene Chr11:108419255-108508351 (-)
DBA/2J MGP_DBA2J_G0018896
 protein coding gene Chr11:96353944-96437236 (-)
FVB/NJ MGP_FVBNJ_G0018885
 protein coding gene Chr11:95863653-95948470 (-)
LP/J MGP_LPJ_G0018966
 protein coding gene Chr11:101489245-101577931 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018912
 protein coding gene Chr11:108201952-108287972 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019496
 protein coding gene Chr11:100142661-100228245 (-)
PWK/PhJ MGP_PWKPhJ_G0018143
 protein coding gene Chr11:97362375-97448148 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017933
 protein coding gene Chr11:99843417-99925421 (-)
WSB/EiJ MGP_WSBEiJ_G0018421
 protein coding gene Chr11:100058310-100155977 (-)



Homology
more
  • Human Ortholog
    IKZF3, IKAROS family zinc finger 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IKZF3, IKAROS family zinc finger 3
  • Synonyms
    AIO, AIOLOS, IMD84, ZNFN1A3
  • Links
    NCBI Gene ID: 22806
    neXtProt AC: NX_Q9UKT9
    UniProt: Q9UKT9

  • Chr Location
    17q12-q21.1; chr17:39757715-39864312 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ikzf3 mouse models; 1 with human IKZF3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit greatly reduced B cell populations in the peritoneum, marginal zone and recirculating bone marrow. Aging mutants express autoantibodies, frequently develop B cell lymphomas, and display symptoms characteristic of SLE.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1082
  • Tissues
    214
  • cDNA Data
    17
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018168 Ensembl Gene Model | MGI Sequence Detail 81130 C57BL/6J ±  kb
    transcript ENSMUST00000103141 Ensembl | MGI Sequence Detail 3658 Not Applicable  
    polypeptide ENSMUSP00000099430 Ensembl | MGI Sequence Detail 507 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 1
      cDNA 19
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1926180, MGI:891998
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 8
      Diseases 2
      Gene Ontology 12
      Phenotypes 30
    • Earliest
      J:40023 Morgan B, et al., Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 1997 Apr 15;16(8):2004-13
    • Latest
      J:357485 Yomogida K, et al., The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes. Nat Immunol. 2024 Jan;25(1):77-87
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory