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Klf2 Gene Detail
Summary
  • Symbol
    Klf2
  • Name
    Kruppel-like transcription factor 2 (lung)
  • Synonyms
    Lklf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342772
    NCBI Gene: 16598
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:73072906-73075498 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.99 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342772
 protein coding gene Chr8:73072877-73075500 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033779
 protein coding gene Chr8:72800536-72803160 (+)
A/J MGP_AJ_G0033761
 protein coding gene Chr8:69855381-69858004 (+)
AKR/J MGP_AKRJ_G0033688
 protein coding gene Chr8:71919506-71922130 (+)
BALB/cJ MGP_BALBcJ_G0033755
 protein coding gene Chr8:69987710-69990334 (+)
C3H/HeJ MGP_C3HHeJ_G0033464
 protein coding gene Chr8:72551431-72554055 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034275
 protein coding gene Chr8:75561807-75564430 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031216
 protein coding gene Chr8:64372568-64375210 (+)
CAST/EiJ MGP_CASTEiJ_G0032793
 protein coding gene Chr8:71902797-71905420 (+)
CBA/J MGP_CBAJ_G0033443
 protein coding gene Chr8:78266195-78268819 (+)
DBA/2J MGP_DBA2J_G0033597
 protein coding gene Chr8:69597419-69600043 (+)
FVB/NJ MGP_FVBNJ_G0033542
 protein coding gene Chr8:68672012-68674636 (+)
LP/J MGP_LPJ_G0033686
 protein coding gene Chr8:72889967-72892591 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033586
 protein coding gene Chr8:80757201-80759824 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034292
 protein coding gene Chr8:71988148-71990772 (+)
PWK/PhJ MGP_PWKPhJ_G0032499
 protein coding gene Chr8:68855940-68858655 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032336
 protein coding gene Chr8:70912421-70915053 (+)
WSB/EiJ MGP_WSBEiJ_G0032908
 protein coding gene Chr8:72294243-72296865 (+)



Homology
more
  • Human Ortholog
    KLF2, KLF transcription factor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLF2, KLF transcription factor 2
  • Synonyms
    LKLF
  • Links
    NCBI Gene ID: 10365
    neXtProt AC: NX_Q9Y5W3
    UniProt: Q9Y5W3

  • Chr Location
    19p13.11; chr19:16324826-16328685 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 6 alleles in 9 genetic backgrounds
    2 phenotypes from multigenic genotypes
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted null mutations die during organogenesis with growth retardation, massive hemorrhage, and signs of anemia. Mice homozygous for one allele also display craniofacial malformations and impaired hematopoiesis. A second allele causes vascular abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1088
  • Tissues
    204
  • cDNA Data
    75
  • Literature Summary
    51
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16598 NCBI Gene Model | MGI Sequence Detail 2593 C57BL/6J ±  kb
    transcript NM_008452 RefSeq | MGI Sequence Detail 1816 C57BL/6  
    polypeptide Q60843 UniProt | EBI | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 91
      Genomic 3
      cDNA 78
      Primer pair 9
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-27042, MGI:104679
    References
    more
    • Summaries
      All 172
      Developmental Gene Expression 51
      Gene Ontology 13
      Phenotypes 77
    • Earliest
      J:29401 Anderson KP, et al., Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Kruppel-like factor: identification of a new multigene family. Mol Cell Biol. 1995 Nov;15(11):5957-65
    • Latest
      J:355268 Huang Y, et al., The role of KLF2 in regulating hepatic lipogenesis and blood cholesterol homeostasis via the SCAP/SREBP pathway. J Lipid Res. 2024 Jan;65(1):100472
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory