About   Help   FAQ
Tnfrsf17 Gene Detail
Summary
  • Symbol
    Tnfrsf17
  • Name
    tumor necrosis factor receptor superfamily, member 17
  • Synonyms
    BCM, BCMA, Tnfrsf13, Tnfrsf13a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343050
    NCBI Gene: 21935
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr16:11131676-11137938 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 6.42 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    218 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343050
 protein coding gene Chr16:11131131-11137938 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022524
 protein coding gene Chr16:8193874-8200078 (+)
A/J MGP_AJ_G0022486
 protein coding gene Chr16:7731562-7738815 (+)
AKR/J MGP_AKRJ_G0022462
 protein coding gene Chr16:8096218-8102480 (+)
BALB/cJ MGP_BALBcJ_G0022490
 protein coding gene Chr16:7876460-7882707 (+)
C3H/HeJ MGP_C3HHeJ_G0022257
 protein coding gene Chr16:8162624-8168884 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022939
 protein coding gene Chr16:8353950-8360211 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020459
 protein coding gene Chr16:7893247-7900126 (+)
CAST/EiJ MGP_CASTEiJ_G0021784
 protein coding gene Chr16:8194627-8200894 (+)
CBA/J MGP_CBAJ_G0022226
 protein coding gene Chr16:8708878-8715332 (+)
DBA/2J MGP_DBA2J_G0022357
 protein coding gene Chr16:7739781-7745884 (+)
FVB/NJ MGP_FVBNJ_G0022333
 protein coding gene Chr16:7728838-7735291 (+)
LP/J MGP_LPJ_G0022425
 protein coding gene Chr16:8129502-8135693 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022355
 protein coding gene Chr16:8405456-8411664 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022952
 protein coding gene Chr16:8037896-8043999 (+)
PWK/PhJ MGP_PWKPhJ_G0021524
 protein coding gene Chr16:7975259-7981706 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021354
 protein coding gene Chr16:8098452-8105869 (+)
WSB/EiJ MGP_WSBEiJ_G0021832
 protein coding gene Chr16:8119068-8125373 (+)



Homology
more
  • Human Ortholog
    TNFRSF17, TNF receptor superfamily member 17
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFRSF17, TNF receptor superfamily member 17
  • Synonyms
    BCM, BCMA, CD269, TNFRSF13A
  • Links
    NCBI Gene ID: 608
    neXtProt AC: NX_Q02223
    UniProt: Q02223

  • Chr Location
    16p13.13; chr16:11965210-11968068 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TNFRSF17 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted null mutations in this gene are viable and fertile with no apparent defects in immune system development or function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    779
  • Tissues
    44
  • cDNA Data
    6
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022496 Ensembl Gene Model | MGI Sequence Detail 6263 C57BL/6J ±  kb
    transcript ENSMUST00000023140 Ensembl | MGI Sequence Detail 815 Not Applicable  
    polypeptide ENSMUSP00000023140 Ensembl | MGI Sequence Detail 185 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 6
      Primer pair 1
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 20
    • Earliest
      J:51039 Madry C, et al., The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily. Int Immunol. 1998 Nov;10(11):1693-702
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory