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Aif1 Gene Detail
Summary
  • Symbol
    Aif1
  • Name
    allograft inflammatory factor 1
  • Synonyms
    D17H6S50E, G1, Iba1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343098
    NCBI Gene: 11629
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35389967-35394977 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.59 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343098
 protein coding gene Chr17:35389967-35395044 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023625
 protein coding gene Chr17:35316149-35321951 (-)
A/J MGP_AJ_G0023585
 protein coding gene Chr17:34143117-34148197 (-)
AKR/J MGP_AKRJ_G0023553
 protein coding gene Chr17:34620588-34625412 (-)
BALB/cJ MGP_BALBcJ_G0023591
 protein coding gene Chr17:34283580-34288819 (-)
C3H/HeJ MGP_C3HHeJ_G0023352
 protein coding gene Chr17:35022763-35028753 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024030
 protein coding gene Chr17:36659122-36665823 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021511
 protein coding gene Chr17:31914522-31919515 (-)
CAST/EiJ MGP_CASTEiJ_G0022848
 protein coding gene Chr17:35019755-35024876 (-)
CBA/J MGP_CBAJ_G0023330
 protein coding gene Chr17:38164858-38171972 (-)
DBA/2J MGP_DBA2J_G0023458
 protein coding gene Chr17:33467909-33472700 (-)
FVB/NJ MGP_FVBNJ_G0023425
 protein coding gene Chr17:33309502-33314636 (-)
LP/J MGP_LPJ_G0023535
 protein coding gene Chr17:35644689-35652291 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023447
 protein coding gene Chr17:37098318-37104568 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024075
 protein coding gene Chr17:34847095-34851866 (-)
PWK/PhJ MGP_PWKPhJ_G0022596
 protein coding gene Chr17:32302577-32309668 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022416
 protein coding gene Chr17:32854684-32860776 (-)
WSB/EiJ MGP_WSBEiJ_G0022912
 protein coding gene Chr17:34968839-34973609 (-)



Homology
more
  • Human Ortholog
    AIF1, allograft inflammatory factor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AIF1, allograft inflammatory factor 1
  • Synonyms
    AIF-1, IBA1, IRT-1, IRT1
  • Links
    NCBI Gene ID: 199
    neXtProt AC: NX_P55008
    UniProt: P55008

  • Chr Location
    6p21.33; chr6:31615217-31617021 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human AIF1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased spleen weight, decreased platalet cell number and decreased susceptibility to induced arthritis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    84
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    892
  • Tissues
    63
  • cDNA Data
    25
  • Literature Summary
    220
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11629 NCBI Gene Model | MGI Sequence Detail 5011 C57BL/6J ±  kb
    transcript NM_001409899 RefSeq | MGI Sequence Detail 947 ZRU/MplStud  
    polypeptide O70200 UniProt | EBI | MGI Sequence Detail 147 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 8
      cDNA 26
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-4478, MGI:2146897, MGI:90671
    References
    more
    • Summaries
      All 291
      Developmental Gene Expression 220
      Gene Ontology 9
      Phenotypes 26
    • Earliest
      J:14354 Lund T, et al., RFLP analysis of the MHC class III region defines unique haplotypes for the non-obese diabetic, cataract Shionogi and the non-obese non-diabetic mouse strains. Diabetologia. 1993 Aug;36(8):727-33
    • Latest
      J:355331 Mao Y, et al., Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance. J Neuroinflammation. 2024 Oct 4;21(1):249
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory