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Hpse Gene Detail
Summary
  • Symbol
    Hpse
  • Name
    heparanase
  • Synonyms
    Hpa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343124
    NCBI Gene: 15442
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:100827350-100867582 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 48.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1365 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343124
 protein coding gene Chr5:100827350-100867582 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029790
 protein coding gene Chr5:102184765-102231254 (-)
A/J MGP_AJ_G0029756
 protein coding gene Chr5:98377682-98417767 (-)
AKR/J MGP_AKRJ_G0029702
 protein coding gene Chr5:101619326-101662158 (-)
BALB/cJ MGP_BALBcJ_G0029766
 protein coding gene Chr5:99407987-99447955 (-)
C3H/HeJ MGP_C3HHeJ_G0029489
 protein coding gene Chr5:101968667-102009616 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030221
 protein coding gene Chr5:106431928-106477200 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027456
 protein coding gene Chr5:93621317-93660898 (-)
CAST/EiJ MGP_CASTEiJ_G0028900
 protein coding gene Chr5:100625773-100673959 (-)
CBA/J MGP_CBAJ_G0029459
 protein coding gene Chr5:110126158-110173392 (-)
DBA/2J MGP_DBA2J_G0029603
 protein coding gene Chr5:98570961-98611082 (-)
FVB/NJ MGP_FVBNJ_G0029562
 protein coding gene Chr5:97370542-97410394 (-)
LP/J MGP_LPJ_G0029691
 protein coding gene Chr5:102799622-102843737 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029591
 protein coding gene Chr5:115190900-115239945 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030254
 protein coding gene Chr5:101098853-101140193 (-)
PWK/PhJ MGP_PWKPhJ_G0028618
 protein coding gene Chr5:97005001-97046927 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028453
 protein coding gene Chr5:98771669-98815186 (-)
WSB/EiJ MGP_WSBEiJ_G0028978
 protein coding gene Chr5:101435428-101479301 (-)



Homology
more
  • Human Ortholog
    HPSE, heparanase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HPSE, heparanase
  • Synonyms
    HPA, HPA1, HPR1, HPSE1, HSE1
  • Links
    NCBI Gene ID: 10855
    neXtProt AC: NX_Q9Y251
    UniProt: Q9Y251

  • Chr Location
    4q21.23; chr4:83292461-83335153 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    2 images
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit precocious mammry gland development, increased angiogenesis and increased neovascularization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    924
  • Tissues
    123
  • cDNA Data
    33
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15442 NCBI Gene Model | MGI Sequence Detail 40233 C57BL/6J ±  kb
    transcript NM_152803 RefSeq | MGI Sequence Detail 3140 Not Specified  
    polypeptide Q6YGZ1 UniProt | EBI | MGI Sequence Detail 535 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 33
      Primer pair 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 14
      Gene Ontology 15
      Phenotypes 48
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345972 Martinez HA, et al., Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue. Nat Commun. 2024 Feb 20;15(1):1564
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory