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Gnpat Gene Detail
Summary
  • Symbol
    Gnpat
  • Name
    glyceronephosphate O-acyltransferase
  • Synonyms
    D1Ertd819e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343460
    NCBI Gene: 14712
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:125589772-125616796 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    774 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343460
 protein coding gene Chr8:125589772-125616796 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034280
 protein coding gene Chr8:128572650-128604583 (+)
A/J MGP_AJ_G0034260
 protein coding gene Chr8:123236479-123268715 (+)
AKR/J MGP_AKRJ_G0034187
 protein coding gene Chr8:126798426-126828734 (+)
BALB/cJ MGP_BALBcJ_G0034253
 protein coding gene Chr8:123422570-123449768 (+)
C3H/HeJ MGP_C3HHeJ_G0033964
 protein coding gene Chr8:127446931-127476991 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034773
 protein coding gene Chr8:132861585-132892369 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031714
 protein coding gene Chr8:115998248-116026531 (+)
CAST/EiJ MGP_CASTEiJ_G0033291
 protein coding gene Chr8:127568595-127597730 (+)
CBA/J MGP_CBAJ_G0033937
 protein coding gene Chr8:137739854-137769856 (+)
DBA/2J MGP_DBA2J_G0034093
 protein coding gene Chr8:122402786-122430681 (+)
FVB/NJ MGP_FVBNJ_G0034037
 protein coding gene Chr8:121581141-121608082 (+)
LP/J MGP_LPJ_G0034182
 protein coding gene Chr8:128732200-128766571 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034084
 protein coding gene Chr8:139816828-139845021 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034792
 protein coding gene Chr8:127037015-127069658 (+)
PWK/PhJ MGP_PWKPhJ_G0032993
 protein coding gene Chr8:122159451-122187163 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032832
 protein coding gene Chr8:125668451-125696926 (+)
WSB/EiJ MGP_WSBEiJ_G0033408
 protein coding gene Chr8:127753940-127784792 (+)



Homology
more
  • Human Ortholog
    GNPAT, glyceronephosphate O-acyltransferase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNPAT, glyceronephosphate O-acyltransferase
  • Synonyms
    DAP-AT, DAPAT, DHAPAT, RCDP2
  • Links
    NCBI Gene ID: 8443
    neXtProt AC: NX_O15228
    UniProt: O15228

  • Chr Location
    1q42.2; chr1:231241207-231277973 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Gnpat mouse models; 1 with human GNPAT associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 1 allele in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice lack plasmalogens due to inactivation of ether lipid synthesis. Mutant mice exhibit dwarfism, male infertility, defects in eye development, and optic nerve hypoplasia. While some mice die prematurely, others, particularly females, are long-lived.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    817
  • Tissues
    106
  • cDNA Data
    175
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14712 NCBI Gene Model | MGI Sequence Detail 27025 C57BL/6J ±  kb
    transcript NM_010322 RefSeq | MGI Sequence Detail 2984 ZRU/MplStud  
    polypeptide P98192 UniProt | EBI | MGI Sequence Detail 678 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000008121 dihydroxyacetone phosphate acyltransferase
      (term hierarchy)
    • EC
      2.3.1.42
    • InterPro Domains
      IPR028353 Dihydroxyacetone phosphate acyltransferase
      IPR022284 Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase
      IPR041728 GPAT/DHAPAT, acyltransferase domain
      IPR045520 GPAT/DHAPAT, C-terminal domain
      IPR002123 Phospholipid/glycerol acyltransferase
    Molecular
    Reagents
    less
    • All nucleic 176
      cDNA 175
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1289284, MGI:2142692
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 12
      Phenotypes 28
    • Earliest
      J:56268 Ofman R, et al., Identification and characterization of the mouse cDNA encoding acyl-CoA:dihydroxyacetone phosphate acyltransferase. Biochim Biophys Acta. 1999 Jul 9;1439(1):89-94
    • Latest
      J:336285 Dorninger F, et al., Overlapping and Distinct Features of Cardiac Pathology in Inherited Human and Murine Ether Lipid Deficiency. Int J Mol Sci. 2023 Jan 18;24(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory