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Grem1 Gene Detail
Summary
  • Symbol
    Grem1
  • Name
    gremlin 1, DAN family BMP antagonist
  • Synonyms
    Cktsf1b1, Drm, Grem, gremlin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344337
    NCBI Gene: 23892
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
  • Regulated by
    Rr290, Rr289, Rr288 ... (8 regulatory regions)
Location &
Maps
more
  • Sequence Map
    Chr2:113579020-113588993 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 57.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    316 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344337
 protein coding gene Chr2:113576509-113588993 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026297
 protein coding gene Chr2:116215446-116232508 (-)
A/J MGP_AJ_G0026258
 protein coding gene Chr2:111491494-111504886 (-)
AKR/J MGP_AKRJ_G0026237
 protein coding gene Chr2:114589970-114611097 (-)
BALB/cJ MGP_BALBcJ_G0026271
 protein coding gene Chr2:111722884-111737096 (-)
C3H/HeJ MGP_C3HHeJ_G0026016
 protein coding gene Chr2:115013191-115026383 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026718
 protein coding gene Chr2:120071401-120088990 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024098
 protein coding gene Chr2:106660251-106673062 (-)
CAST/EiJ MGP_CASTEiJ_G0025479
 protein coding gene Chr2:115310301-115333066 (-)
CBA/J MGP_CBAJ_G0025993
 protein coding gene Chr2:124262121-124279419 (-)
DBA/2J MGP_DBA2J_G0026132
 protein coding gene Chr2:110945451-110958027 (-)
FVB/NJ MGP_FVBNJ_G0026094
 protein coding gene Chr2:109804404-109816413 (-)
LP/J MGP_LPJ_G0026233
 protein coding gene Chr2:116524611-116539389 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026113
 protein coding gene Chr2:128658792-128673335 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026773
 protein coding gene Chr2:114669064-114682517 (-)
PWK/PhJ MGP_PWKPhJ_G0025215
 protein coding gene Chr2:110455853-110469954 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025014
 protein coding gene Chr2:113823843-113837606 (-)
WSB/EiJ MGP_WSBEiJ_G0025548
 protein coding gene Chr2:115491763-115505465 (-)



Homology
more
  • Human Ortholog
    GREM1, gremlin 1, DAN family BMP antagonist
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GREM1, gremlin 1, DAN family BMP antagonist
  • Synonyms
    C15DUPq, CKTSF1B1, CRAC1, CRCS4, DAND2, DRM, DUP15q, GREMLIN, HMPS, HMPS1, IHG-2, MPSH, PIG2
  • Links
    NCBI Gene ID: 26585
    neXtProt AC: NX_O60565
    UniProt: O60565

  • Chr Location
    15q13.3; chr15:32718004-32745106 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    59 phenotypes from 6 alleles in 12 genetic backgrounds
    14 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality with bilateral agenesis of the kidneys and ureters, oligodactyly, limb skeletal malformations, cyanosis, dyspnea, and abnormal lung morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    92
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1123
  • Tissues
    100
  • cDNA Data
    15
  • Literature Summary
    168
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23892 NCBI Gene Model | MGI Sequence Detail 9974 C57BL/6J ±  kb
    transcript NM_011824 RefSeq | MGI Sequence Detail 1639 Not Specified  
    polypeptide O70326 UniProt | EBI | MGI Sequence Detail 184 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      Genomic 3
      cDNA 16
      Primer pair 9
      Other 27

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1344362
    References
    more
    • Summaries
      All 268
      Developmental Gene Expression 168
      Gene Ontology 18
      Phenotypes 71
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:363261 He T, et al., Endothelial PD-1 Regulates Vascular Homeostasis and Oligodendrogenesis during Brain Development. Adv Sci (Weinh). 2025 Feb 27;:e2417410
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory