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Tiam2 Gene Detail
Summary
  • Symbol
    Tiam2
  • Name
    T cell lymphoma invasion and metastasis 2
  • Synonyms
    3000002F19Rik, mKIAA2016, STEF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344338
    NCBI Gene: 24001
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:3376675-3569672 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 1.99 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6071 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344338
 protein coding gene Chr17:3376675-3581619 (+)
129S1/SvImJ ENSMUSG00200031437
 protein coding gene Chr17:256454-462876 (+)
A/J ENSMUSG00195023219
 protein coding gene Chr17:252509-458022 (+)
AKR/J ENSMUSG00220026041
 protein coding gene Chr17:438423-643257 (+)
BALB/cJ ENSMUSG00180024080
 protein coding gene Chr17:264414-469928 (+)
C3H/HeJ ENSMUSG00175030664
 protein coding gene Chr17:224553-430038 (+)
C57BL/6NJ ENSMUSG00215014829
 protein coding gene Chr17:257695-462613 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021017
 protein coding gene Chr17:235853-427663 (+)
CAST/EiJ ENSTCUG00005021424
 protein coding gene Chr17:297617-502577 (+)
CBA/J ENSMUSG00210032032
 protein coding gene Chr17:241612-447094 (+)
DBA/2J ENSMUSG00185021848
 protein coding gene Chr17:345534-554561 (+)
FVB/NJ ENSMUSG00205007283
 protein coding gene Chr17:290634-499669 (+)
JF1/MsJ ENSUMUG00000019799
 protein coding gene Chr17:323322-533031 (+)
LP/J ENSMUSG00230033967
 protein coding gene Chr17:1454389-1659297 (+)
NOD/ShiLtJ ENSMUSG00190024782
 protein coding gene Chr17:224211-433795 (+)
NZO/HlLtJ ENSMUSG00225028930
 protein coding gene Chr17:3745279-3950192 (+)
PWK/PhJ ENSLUMG00010018323
 protein coding gene Chr17:355977-562527 (+)
SPRET/EiJ ENSMSPG00010034867
 protein coding gene Chr17:317536-421709 (+)
WSB/EiJ ENSIUOG00005013298
 protein coding gene Chr17:286768-491756 (+)



Homology
more
  • Human Ortholog
    TIAM2, TIAM Rac1 associated GEF 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIAM2, TIAM Rac1 associated GEF 2
  • Synonyms
    STEF, TIAM-2
  • Links
    NCBI Gene ID: 26230
    UniProt: Q8IVF5

  • Chr Location
    6q25.2-q25.3; chr6:154832697-155257723 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    7 phenotype references
Mcie heterozygous for a knock-out allele exhibit reduced transmission of the t-haplotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    75
  • cDNA Data
    17
  • Literature Summary
    13
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 24001 NCBI Gene Model | MGI Sequence Detail 192998 C57BL/6J ±  kb
transcript NM_001122998 RefSeq | MGI Sequence Detail 6144 ZRU/MplStud  
polypeptide Q6ZPF3 UniProt | EBI | MGI Sequence Detail 1715 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 1
    cDNA 18
    Other 2
    Antibodies 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2447820
References
more
  • Summaries
    All 55
    Developmental Gene Expression 13
    Gene Ontology 10
    Phenotypes 7
  • Earliest
    J:50543 Kawasaki H, et al., A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia [published erratum appears in Proc Natl Acad Sci U S A 1999 Jan 5;96(1):318]. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13278-83
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory