Grem2 MGI Mouse Gene Detail - MGI:1344367 - gremlin 2, DAN family BMP antagonist

Symbol

Grem2
Name

gremlin 2, DAN family BMP antagonist
Synonyms

Prdc

Feature Type

protein coding gene
IDs

MGI:1344367
NCBI Gene: 23893
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:174661352-174749386 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 81.08 cM, cytoband H3
Mapping Data

1 experiment

SNPs within 2kb

2408 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1344367	protein coding gene	Chr1:174661351-174749386 (-)
129S1/SvImJ	ENSMUSG00200042741	protein coding gene	Chr1:172415250-172505879 (-)
A/J	ENSMUSG00195047705	protein coding gene	Chr1:171832353-171922865 (-)
AKR/J	ENSMUSG00220031232	protein coding gene	Chr1:171409958-171500504 (-)
BALB/cJ	ENSMUSG00180041998	protein coding gene	Chr1:172066872-172157506 (-)
C3H/HeJ	ENSMUSG00175045657	protein coding gene	Chr1:172243081-172333721 (-)
C57BL/6NJ	ENSMUSG00215042117	protein coding gene	Chr1:171622059-171710134 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014941	protein coding gene	Chr1:164978014-165072323 (-)
CAST/EiJ	ENSTCUG00005045257	protein coding gene	Chr1:170162113-170252063 (-)
CBA/J	ENSMUSG00210041583	protein coding gene	Chr1:171887904-171978508 (-)
DBA/2J	ENSMUSG00185029809	protein coding gene	Chr1:176500659-176591261 (-)
FVB/NJ	ENSMUSG00205031706	protein coding gene	Chr1:170978018-171068528 (-)
JF1/MsJ	ENSUMUG00000016515	protein coding gene	Chr1:175336527-175424622 (-)
LP/J	ENSMUSG00230030178	protein coding gene	Chr1:176082218-176172856 (-)
NOD/ShiLtJ	ENSMUSG00190031239	protein coding gene	Chr1:171917700-172008331 (-)
NZO/HlLtJ	ENSMUSG00225004571	protein coding gene	Chr1:179680949-179833978 (-)
PWK/PhJ	ENSLUMG00010030808	protein coding gene	Chr1:170619996-170710650 (-)
SPRET/EiJ	ENSMSPG00010029756	protein coding gene	Chr1:174262422-174353968 (-)
WSB/EiJ	ENSIUOG00005034270	protein coding gene	Chr1:170996217-171086730 (-)

Human Ortholog

GREM2, gremlin 2, DAN family BMP antagonist

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GREM2, gremlin 2, DAN family BMP antagonist
Synonyms

CKTSF1B2, DAND3, PRDC, STHAG9
Links

HGNC:17655

NCBI Gene ID: 64388

UniProt: Q9H772
Chr Location

1q43; chr1:240489573-240612155 (-) GRCh38

MGI Vertebrate Homology

Grem2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GREM2
Protein SuperFamily

Gremlin_precursor
Gene Tree

Grem2

Diseases

1 with human GREM2 associations

				Human Disease	Mouse Models
				tooth agenesis IDs tooth agenesis DOID:0050591 ICD10CM:K00.0 ICD9CM:520.0 MESH:D000848 OMIM:106600 OMIM:150400 OMIM:313500 OMIM:602639 OMIM:604625 OMIM:610926 OMIM:PS106600 ORDO:2227 ORDO:99798 UMLS_CUI:C0399352

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

50 phenotypes from 5 alleles in 5 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

2
Endonuclease-mediated

7
Gene trapped

1
Targeted

4
Transgenic

1
Genomic Mutations

2 involving Grem2
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele have malformed incisors but no bone defects. Homozygotes for a second null allele display excessive inflammation after myocardial infarction. Homozygotes for a third null allele show female subfertility, altered estrous cycles and low anti-Mullerian hormone levels.

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

649
Tissues

25
cDNA Data

22
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN grem2b

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All Sequences

39
RefSeq

10
UniProt

2
CCDS

CCDS15545.1

Ensembl

ENSMUSG00000050069 (Evidence)
NCBI Gene

23893

			Length	Strain/Species	Flank
genomic	23893	NCBI Gene Model \| MGI Sequence Detail	88035	C57BL/6J	± kb
transcript	NM_001421484	RefSeq \| MGI Sequence Detail	3937	C57BL/6
polypeptide	O88273	UniProt \| EBI \| MGI Sequence Detail	168	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008228 gremlin-2

(term hierarchy)
PDB

4JPH, 5HK5
InterPro Domains

IPR006207 Cystine knot, C-terminal

IPR029034 Cystine-knot cytokine

IPR004133 DAN

IPR017159 Gremlin-1/2
GlyGen

O88273 2 sites, 1 N-linked glycan (1 site)

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All nucleic 26

cDNA 23

Primer pair 1

Other 2

Microarray probesets 3

Summaries

All 67

Developmental Gene Expression 11

Gene Ontology 5

Phenotypes 16
Earliest

J:31883 Ozaki T, et al., Cloning of mouse DAN cDNA and its down-regulation in transformed cells. Jpn J Cancer Res. 1996 Jan;87(1):58-61
Latest

J:366429 Frazer NB, et al., BMP Antagonist Gremlin 2 Regulates Hippocampal Neurogenesis and Is Associated with Seizure Susceptibility and Anxiety. eNeuro. 2024 Oct;11(10):ENEURO.0213-23.2024

TSS for Grem2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15389	Chr1:174749379-174749393 (-)	0 bp
Tssr15388	Chr1:174749357-174749369 (-)	23 bp
Tssr15387	Chr1:174749330-174749337 (-)	52 bp
Tssr15386	Chr1:174749313-174749322 (-)	68 bp
Tssr15385	Chr1:174749287-174749290 (-)	97 bp
Tssr15384	Chr1:174749262-174749273 (-)	118 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24