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Prkra Gene Detail
Summary
  • Symbol
    Prkra
  • Name
    protein kinase, interferon inducible double stranded RNA dependent activator
  • Synonyms
    lear, Pact, PRK, RAX
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344375
    NCBI Gene: 23992
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:76460242-76478359 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 45.07 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    466 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344375
 protein coding gene Chr2:76436385-76478614 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025866
 protein coding gene Chr2:77024843-77042783 (-)
A/J MGP_AJ_G0025843
 protein coding gene Chr2:74032768-74055287 (-)
AKR/J MGP_AKRJ_G0025812
 protein coding gene Chr2:76027494-76045430 (-)
BALB/cJ MGP_BALBcJ_G0025838
 protein coding gene Chr2:74211814-74229789 (-)
C3H/HeJ MGP_C3HHeJ_G0025598
 protein coding gene Chr2:76232698-76250646 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026285
 protein coding gene Chr2:79308038-79327195 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023688
 protein coding gene Chr2:71441115-71459042 (-)
CAST/EiJ MGP_CASTEiJ_G0025060
 protein coding gene Chr2:76571087-76589443 (-)
CBA/J MGP_CBAJ_G0025579
 protein coding gene Chr2:82241995-82263596 (-)
DBA/2J MGP_DBA2J_G0025710
 protein coding gene Chr2:73625464-73643453 (-)
FVB/NJ MGP_FVBNJ_G0025672
 protein coding gene Chr2:73018022-73035951 (-)
LP/J MGP_LPJ_G0025798
 protein coding gene Chr2:76908021-76926748 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025703
 protein coding gene Chr2:84066180-84084989 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026341
 protein coding gene Chr2:76152370-76171515 (-)
PWK/PhJ MGP_PWKPhJ_G0024803
 protein coding gene Chr2:73586701-73605024 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024609
 protein coding gene Chr2:76401711-76421054 (-)
WSB/EiJ MGP_WSBEiJ_G0025129
 protein coding gene Chr2:76618606-76639053 (-)



Homology
more
  • Human Ortholog
    PRKRA, protein activator of interferon induced protein kinase EIF2AK2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKRA, protein activator of interferon induced protein kinase EIF2AK2
  • Synonyms
    DYT16, HSD14, PACT, RAX
  • Links
    NCBI Gene ID: 8575
    neXtProt AC: NX_O75569
    UniProt: O75569

  • Chr Location
    2q31.2; chr2:178431292-178451512 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRKRA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 7 alleles in 8 genetic backgrounds
    11 phenotypes from multigenic genotypes
    4 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a deletion of the entire gene show embryonic lethality prior to implantation. Mice homozygous for a deletion in the last exon are viable but exhibit small size, turbinate hypoplasia, short snout, severe microtia, outer and middle ear defects, and impaired hearing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    29
  • cDNA Data
    52
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002731 Ensembl Gene Model | MGI Sequence Detail 18118 C57BL/6J ±  kb
    transcript ENSMUST00000002808 Ensembl | MGI Sequence Detail 1614 Not Applicable  
    polypeptide ENSMUSP00000002808 Ensembl | MGI Sequence Detail 313 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000013241 interferon-inducible double-stranded RNA-dependent protein kinase activator A
      (term hierarchy)
    • InterPro Domains
      IPR014720 Double-stranded RNA-binding domain
      IPR044465 PRKRA, first double-stranded RNA binding domain
      IPR044466 PRKRA, second double-stranded RNA binding domain
      IPR044467 PRKRA, third double-stranded RNA binding domain
      IPR051247 RISC Loading Complex Component
    • GlyGen
      Q9WTX2 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 53
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139255, MGI:4439143
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 7
      Gene Ontology 12
      Phenotypes 22
    • Earliest
      J:55431 Ito T, et al., RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling. J Biol Chem. 1999 May 28;274(22):15427-32
    • Latest
      J:349355 Wu Y, et al., Decreased Tiam1-mediated Rac1 activation is responsible for impaired directional persistence of chondrocyte migration in microtia. J Cell Mol Med. 2024 Jun;28(11):e18443
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory