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Sh3bp5 Gene Detail
Summary
  • Symbol
    Sh3bp5
  • Name
    SH3-domain binding protein 5 (BTK-associated)
  • Synonyms
    Sab
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344391
    NCBI Gene: 24056
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:31094571-31158056 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.11 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1954 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344391
 protein coding gene Chr14:31081837-31158056 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021128
 protein coding gene Chr14:24539893-24616994 (-)
A/J MGP_AJ_G0021076
 protein coding gene Chr14:23614414-23691225 (-)
AKR/J MGP_AKRJ_G0021053
 protein coding gene Chr14:24738821-24814907 (-)
BALB/cJ MGP_BALBcJ_G0021080
 protein coding gene Chr14:23739845-23816544 (-)
C3H/HeJ MGP_C3HHeJ_G0020863
 protein coding gene Chr14:24609295-24686489 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021512
 protein coding gene Chr14:25506125-25584100 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019075
 protein coding gene Chr14:23683481-23759194 (-)
CAST/EiJ MGP_CASTEiJ_G0020388
 protein coding gene Chr14:24377769-24458598 (-)
CBA/J MGP_CBAJ_G0020830
 protein coding gene Chr14:26479797-26561291 (-)
DBA/2J MGP_DBA2J_G0020952
 protein coding gene Chr14:23644429-23721460 (-)
FVB/NJ MGP_FVBNJ_G0020936
 protein coding gene Chr14:23605987-23683014 (-)
LP/J MGP_LPJ_G0021021
 protein coding gene Chr14:24865736-24943145 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020962
 protein coding gene Chr14:25744537-25820813 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021545
 protein coding gene Chr14:24500626-24579193 (-)
PWK/PhJ MGP_PWKPhJ_G0020136
 protein coding gene Chr14:23104880-23183760 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019960
 protein coding gene Chr14:24106154-24186185 (-)
WSB/EiJ MGP_WSBEiJ_G0020443
 protein coding gene Chr14:24563980-24642432 (-)



Homology
more
  • Human Ortholog
    SH3BP5, SH3 domain binding protein 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SH3BP5, SH3 domain binding protein 5
  • Synonyms
    SAB, SH3BP-5
  • Links
    NCBI Gene ID: 9467
    neXtProt AC: NX_O60239
    UniProt: O60239

  • Chr Location
    3p25.1; chr3:15254353-15341380 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    45
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 24056 NCBI Gene Model | MGI Sequence Detail 63486 C57BL/6J ±  kb
transcript NM_011894 RefSeq | MGI Sequence Detail 3889 C57BL/6  
polypeptide Q9Z131 UniProt | EBI | MGI Sequence Detail 463 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    cDNA 45

    Microarray probesets 5
Other
Accession IDs
less
MGI:2145681
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:55122 Yamadori T, et al., Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6341-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory