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Pebp1 Gene Detail
Summary
  • Symbol
    Pebp1
  • Name
    phosphatidylethanolamine binding protein 1
  • Synonyms
    Pbp1, Pbpr, Pebp1, Raf-1 inhibitor protein, RKIP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344408
    NCBI Gene: 23980
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:117420716-117425629 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 56.88 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    222 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344408
 protein coding gene Chr5:117420716-117425690 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029985
 protein coding gene Chr5:120354313-120359275 (-)
A/J MGP_AJ_G0029949
 protein coding gene Chr5:115473158-115478471 (-)
AKR/J MGP_AKRJ_G0029888
 protein coding gene Chr5:119195657-119201846 (-)
BALB/cJ MGP_BALBcJ_G0029960
 protein coding gene Chr5:116890832-116895819 (-)
C3H/HeJ MGP_C3HHeJ_G0029680
 protein coding gene Chr5:119715990-119721034 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030415
 protein coding gene Chr5:124937362-124943680 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027641
 protein coding gene Chr5:110233508-110238348 (-)
CAST/EiJ MGP_CASTEiJ_G0029089
 protein coding gene Chr5:118726256-118731465 (-)
CBA/J MGP_CBAJ_G0029648
 protein coding gene Chr5:129762003-129766453 (-)
DBA/2J MGP_DBA2J_G0029798
 protein coding gene Chr5:115570541-115574995 (-)
FVB/NJ MGP_FVBNJ_G0029754
 protein coding gene Chr5:114424529-114429652 (-)
LP/J MGP_LPJ_G0029886
 protein coding gene Chr5:120867613-120872588 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029785
 protein coding gene Chr5:133985726-133998268 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030456
 protein coding gene Chr5:118719032-118724029 (-)
PWK/PhJ MGP_PWKPhJ_G0028802
 protein coding gene Chr5:114256687-114263153 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028640
 protein coding gene Chr5:116284413-116289638 (-)
WSB/EiJ MGP_WSBEiJ_G0029164
 protein coding gene Chr5:119297531-119302997 (-)



Homology
more
  • Human Ortholog
    PEBP1, phosphatidylethanolamine binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PEBP1, phosphatidylethanolamine binding protein 1
  • Synonyms
    HCNP, HCNPpp, HEL-210, HEL-S-34, HEL-S-96, PBP, PEBP, PEBP-1, RKIP
  • Links
    NCBI Gene ID: 5037
    neXtProt AC: NX_P30086
    UniProt: P30086

  • Chr Location
    12q24.23; chr12:118136124-118145584 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PEBP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit age-related decrease in olfactory function. Conditional KO in neurons affects cholinergic neuronal axon projections to the hippocampus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    5
  • cDNA Data
    8
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23980 NCBI Gene Model | MGI Sequence Detail 4914 C57BL/6J ±  kb
    transcript NM_018858 RefSeq | MGI Sequence Detail 1217 Not Specified  
    polypeptide P70296 UniProt | EBI | MGI Sequence Detail 187 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • PDB
      6ENS
    • InterPro Domains
      IPR036610 PEBP-like superfamily
      IPR001858 Phosphatidylethanolamine-binding, conserved site
      IPR008914 Phosphatidylethanolamine-binding protein
      IPR035810 Phosphatidylethanolamine-binding protein, eukaryotic
    • GlyGen
      P70296 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 9
      Primer pair 1
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-36368, MGI:107791
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 40
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory