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Ash2l Gene Detail
Summary
  • Symbol
    Ash2l
  • Name
    ASH2 like histone lysine methyltransferase complex subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344416
    NCBI Gene: 23808
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:26306028-26337722 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 14.17 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    724 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344416
 protein coding gene Chr8:26306024-26337722 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033490
 protein coding gene Chr8:23888349-23910927 (-)
A/J MGP_AJ_G0033470
 protein coding gene Chr8:23021391-23045052 (-)
AKR/J MGP_AKRJ_G0033395
 protein coding gene Chr8:23783884-23806767 (-)
BALB/cJ MGP_BALBcJ_G0033466
 protein coding gene Chr8:23167532-23191597 (-)
C3H/HeJ MGP_C3HHeJ_G0033180
 protein coding gene Chr8:23992035-24014916 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033982
 protein coding gene Chr8:24854660-24882099 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030932
 protein coding gene Chr8:20286410-20310200 (-)
CAST/EiJ MGP_CASTEiJ_G0032506
 protein coding gene Chr8:23442343-23462569 (-)
CBA/J MGP_CBAJ_G0033155
 protein coding gene Chr8:25824905-25859006 (-)
DBA/2J MGP_DBA2J_G0033310
 protein coding gene Chr8:22991158-23014439 (-)
FVB/NJ MGP_FVBNJ_G0033254
 protein coding gene Chr8:22797693-22820575 (-)
LP/J MGP_LPJ_G0033399
 protein coding gene Chr8:23865794-23888674 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033297
 protein coding gene Chr8:25281513-25311632 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034001
 protein coding gene Chr8:23716728-23741122 (-)
PWK/PhJ MGP_PWKPhJ_G0032217
 protein coding gene Chr8:22632622-22655363 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032051
 protein coding gene Chr8:23092031-23115536 (-)
WSB/EiJ MGP_WSBEiJ_G0032622
 protein coding gene Chr8:23937620-23960120 (-)



Homology
more
  • Human Ortholog
    ASH2L, ASH2 like, histone lysine methyltransferase complex subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASH2L, ASH2 like, histone lysine methyltransferase complex subunit
  • Synonyms
    ASH2, ASH2L1, ASH2L2, Bre2
  • Links
    NCBI Gene ID: 9070
    neXtProt AC: NX_Q9UBL3
    UniProt: Q9UBL3

  • Chr Location
    8p11.23; chr8:38105493-38144076 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele die before E8.5-E11.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    821
  • Tissues
    79
  • cDNA Data
    186
  • Literature Summary
    20
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 23808 NCBI Gene Model | MGI Sequence Detail 31695 C57BL/6J ±  kb
transcript NM_001359012 RefSeq | MGI Sequence Detail 3321 C57BL/6  
polypeptide Q91X20 UniProt | EBI | MGI Sequence Detail 623 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 188
    cDNA 186
    Other 2

    Microarray probesets 4
References
more
  • Summaries
    All 75
    Developmental Gene Expression 20
    Gene Ontology 16
    Phenotypes 21
  • Earliest
    J:56105 Ikegawa S, et al., Cloning and characterization of ASH2L and Ash2l, human and mouse homologs of the Drosophila ash2 gene. Cytogenet Cell Genet. 1999;84(3-4):167-72
  • Latest
    J:348702 Wang Q, et al., ASH2L Mediates Epidermal Differentiation and Hair Follicle Morphogenesis through H3K4me3 Modification. J Invest Dermatol. 2024 Apr 4;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory