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Neu2 Gene Detail
Summary
  • Symbol
    Neu2
  • Name
    neuraminidase 2
  • Synonyms
    brain sialidase, cystolic sialidase, MBS, MSS, MTS
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344417
    NCBI Gene: 23956
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:87501749-87525567 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 44.44 cM, cytoband D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    637 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344417
 protein coding gene Chr1:87437611-87525567 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016267
 protein coding gene Chr1:88872027-88969293 (+)
A/J MGP_AJ_G0016248
 protein coding gene Chr1:85541269-85630015 (+)
AKR/J MGP_AKRJ_G0016209
 protein coding gene Chr1:88065547-88155887 (+)
BALB/cJ MGP_BALBcJ_G0016205
 protein coding gene Chr1:85663610-85752066 (+)
C3H/HeJ MGP_C3HHeJ_G0016033
 protein coding gene Chr1:88326049-88419505 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016661
 protein coding gene Chr1:92183040-92266966 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014383
 protein coding gene Chr1:79992528-80078886 (+)
CAST/EiJ MGP_CASTEiJ_G0015618
 protein coding gene Chr1:87540681-87635038 (+)
CBA/J MGP_CBAJ_G0016009
 protein coding gene Chr1:95108114-95208900 (+)
DBA/2J MGP_DBA2J_G0016112
 protein coding gene Chr1:84841343-84928871 (+)
FVB/NJ MGP_FVBNJ_G0016111
 protein coding gene Chr1:83903149-83989759 (+)
LP/J MGP_LPJ_G0016183
 protein coding gene Chr1:89930981-90014007 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016137
 protein coding gene Chr1:98386367-98489057 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016704
 protein coding gene Chr1:88177279-88271800 (+)
PWK/PhJ MGP_PWKPhJ_G0015405
 protein coding gene Chr1:84142518-84223388 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015185
 protein coding gene Chr1:87092283-87175339 (+)
WSB/EiJ MGP_WSBEiJ_G0015682
 protein coding gene Chr1:87850057-87941182 (+)



Homology
more
  • Human Ortholog
    NEU2, neuraminidase 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEU2, neuraminidase 2
  • Synonyms
    SIAL2
  • Links
    NCBI Gene ID: 4759
    neXtProt AC: NX_Q9Y3R4
    UniProt: Q9Y3R4

  • Chr Location
    2q37.1; chr2:233032672-233035057 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show increased triglyceride and free fatty acids with age, development of fatty liver, impaired muscle differentiation and altered muscle morphology, poor exercise performance and obesity with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    100
  • cDNA Data
    14
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23956 NCBI Gene Model | MGI Sequence Detail 23819 C57BL/6J ±  kb
    transcript NM_001420679 RefSeq | MGI Sequence Detail 1825 C57BL/6  
    polypeptide Q9JMH3 UniProt | EBI | MGI Sequence Detail 379 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 14
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:321653 Oh M, et al., Defect in cytosolic Neu2 sialidase abrogates lipid metabolism and impairs muscle function in vivo. Sci Rep. 2022 Feb 25;12(1):3216
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory