Osr1 MGI Mouse Gene Detail - MGI:1344424 - odd-skipped related transcription factor 1

Symbol

Osr1
Name

odd-skipped related transcription factor 1
Synonyms

Odd1

Feature Type

protein coding gene
IDs

MGI:1344424
NCBI Gene: 23967
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr12:9624442-9631500 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 4.05 cM
Mapping Data

3 experiments

SNPs within 2kb

246 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1344424	protein coding gene	Chr12:9620116-9631500 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019593	protein coding gene	Chr12:6684985-6692046 (+)
A/J	MGP_AJ_G0019560	protein coding gene	Chr12:6484386-6491435 (+)
AKR/J	MGP_AKRJ_G0019530	protein coding gene	Chr12:6916392-6923431 (+)
BALB/cJ	MGP_BALBcJ_G0019535	protein coding gene	Chr12:6634514-6641555 (+)
C3H/HeJ	MGP_C3HHeJ_G0019341	protein coding gene	Chr12:6742796-6749857 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019984	protein coding gene	Chr12:6897477-6904522 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017609	protein coding gene	Chr12:6284141-6291146 (+)
CAST/EiJ	MGP_CASTEiJ_G0018897	protein coding gene	Chr12:6741864-6750766 (+)
CBA/J	MGP_CBAJ_G0019312	protein coding gene	Chr12:7471165-7478220 (+)
DBA/2J	MGP_DBA2J_G0019425	protein coding gene	Chr12:6438690-6445737 (+)
FVB/NJ	MGP_FVBNJ_G0019416	protein coding gene	Chr12:6413110-6420145 (+)
LP/J	MGP_LPJ_G0019496	protein coding gene	Chr12:6760600-6767649 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019449	protein coding gene	Chr12:7271624-7278677 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020023	protein coding gene	Chr12:6659562-6666619 (+)
PWK/PhJ	MGP_PWKPhJ_G0018663	protein coding gene	Chr12:6515630-6522717 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018453	protein coding gene	Chr12:6700109-6707162 (+)
WSB/EiJ	MGP_WSBEiJ_G0018948	protein coding gene	Chr12:6692657-6699751 (+)

Human Ortholog

OSR1, odd-skipped related transcription factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OSR1, odd-skipped related transcription factor 1
Synonyms

ODD
Links

HGNC:8111

NCBI Gene ID: 130497

neXtProt AC: NX_Q8TAX0

UniProt: Q8TAX0
Chr Location

2p24.1

MGI Vertebrate Homology

Osr1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: OSR1
Gene Tree

Osr1

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Phenotype Summary

41 phenotypes from 5 alleles in 6 genetic backgrounds
7 phenotypes from multigenic genotypes
1 images
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

5
Targeted

7
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a targeted mutation fail to form atrial septum and exhibit dilated atria with hypoplastic venous valves and blood backflow from the heart into systemic veins. Complete agenesis of adrenal glands, metanephric kidneys, gonads, and defects in pericardium formation are also observed.

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All GO Annotations

70
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1274
Tissues

217
cDNA Data

27
Literature Summary

86

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase osr1

ZFIN osr1

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All Sequences

37
RefSeq

4
UniProt

2
CCDS

CCDS25809.1

Ensembl

ENSMUSG00000048387 (Evidence)
NCBI Gene

23967

			Length	Strain/Species	Flank
genomic	23967	NCBI Gene Model \| MGI Sequence Detail	7059	C57BL/6J	± kb
transcript	NM_011859	RefSeq \| MGI Sequence Detail	2027	ZRU/MplStud
polypeptide	Q9WVG7	UniProt \| EBI \| MGI Sequence Detail	266	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012061 protein odd-skipped-related 1

(term hierarchy)
InterPro Domains

IPR050717 C2H2-type Zinc-Finger Transcription Regulators

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 45

Genomic 1

cDNA 29

Primer pair 7

Other 8

Microarray probesets 3

Summaries

All 133

Developmental Gene Expression 86

Gene Ontology 15

Phenotypes 32
Earliest

J:56366 So PL, et al., Cloning and expression analysis of a mouse gene related to Drosophila odd-skipped. Mech Dev. 1999 Jun;84(1-2):157-60
Latest

J:354194 Oikonomakos I, et al., In vitro differentiation of mouse pluripotent stem cells into corticosteroid-producing adrenocortical cells. Stem Cell Reports. 2024 Sep 10;19(9):1289-1303

TSS for Osr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112771	Chr12:9624437-9624448 (+)	1 bp
Tssr112772	Chr12:9624456-9624476 (+)	24 bp
Tssr112773	Chr12:9624478-9624497 (+)	46 bp
Tssr112774	Chr12:9624511-9624527 (+)	77 bp
Tssr112775	Chr12:9630798-9630810 (+)	6,362 bp
Tssr112776	Chr12:9630819-9630832 (+)	6,384 bp
Tssr112777	Chr12:9630841-9630850 (+)	6,404 bp
Tssr112778	Chr12:9630851-9630872 (+)	6,420 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24