About   Help   FAQ
Lypla1 Gene Detail
Summary
  • Symbol
    Lypla1
  • Name
    lysophospholipase 1
  • Synonyms
    Gm39587, Pla1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344588
    NCBI Gene: 18777
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:4878046-4916958 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 1.79 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1155 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344588
 protein coding gene Chr1:4878011-4918633 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015811
 protein coding gene Chr1:1844953-1888864 (+)
A/J MGP_AJ_G0015793
 protein coding gene Chr1:1921697-1965294 (+)
AKR/J MGP_AKRJ_G0015752
 protein coding gene Chr1:1904246-1947541 (+)
BALB/cJ MGP_BALBcJ_G0015749
 protein coding gene Chr1:1850320-1891994 (+)
C3H/HeJ MGP_C3HHeJ_G0015583
 protein coding gene Chr1:1881327-1923572 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016201
 protein coding gene Chr1:1944939-1989568 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0013923
 protein coding gene Chr1:1603753-1638592 (+)
CAST/EiJ MGP_CASTEiJ_G0015163
 protein coding gene Chr1:2058638-2102988 (+)
CBA/J MGP_CBAJ_G0015557
 protein coding gene Chr1:2065477-2112501 (+)
DBA/2J MGP_DBA2J_G0015655
 protein coding gene Chr1:1833750-1874042 (+)
FVB/NJ MGP_FVBNJ_G0015660
 protein coding gene Chr1:1801960-1842524 (+)
LP/J MGP_LPJ_G0015728
 protein coding gene Chr1:2023047-2068365 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015679
 protein coding gene Chr1:2223449-2274940 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016248
 protein coding gene Chr1:1858918-1905278 (+)
PWK/PhJ MGP_PWKPhJ_G0014947
 protein coding gene Chr1:1762891-1809195 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014727
 protein coding gene Chr1:2035013-2083852 (+)
WSB/EiJ MGP_WSBEiJ_G0015227
 protein coding gene Chr1:1863074-1906056 (+)



Homology
more
  • Human Ortholog
    LYPLA1, lysophospholipase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LYPLA1, lysophospholipase 1
  • Synonyms
    APT-1, APT1, hAPT1, LPL1, LPL-I
  • Links
    NCBI Gene ID: 10434
    neXtProt AC: NX_O75608
    UniProt: O75608

  • Chr Location
    8q11.23; chr8:54046367-54102017 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    851
  • Tissues
    129
  • cDNA Data
    112
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18777 NCBI Gene Model | MGI Sequence Detail 38913 C57BL/6J ±  kb
    transcript NM_008866 RefSeq | MGI Sequence Detail 2436 C57BL/6  
    polypeptide P97823 UniProt | EBI | MGI Sequence Detail 230 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 114
      cDNA 114

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1096318, MGI:5622472
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:40317 Wang A, et al., Cloning, expression, and catalytic mechanism of murine lysophospholipase I. J Biol Chem. 1997 May 9;272(19):12723-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory