Spry1 MGI Mouse Gene Detail - MGI:1345139 - sprouty RTK signaling antagonist 1

Symbol

Spry1
Name

sprouty RTK signaling antagonist 1
Synonyms

sprouty 1, sprouty1

Feature Type

protein coding gene
IDs

MGI:1345139
NCBI Gene: 24063
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:37694096-37698747 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 18.46 cM
Mapping Data

3 experiments

SNPs within 2kb

186 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1345139	protein coding gene	Chr3:37694096-37698748 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027173	protein coding gene	Chr3:35505275-35509242 (+)
A/J	MGP_AJ_G0027133	protein coding gene	Chr3:34784475-34789166 (+)
AKR/J	MGP_AKRJ_G0027102	protein coding gene	Chr3:35441065-35445730 (+)
BALB/cJ	MGP_BALBcJ_G0027145	protein coding gene	Chr3:34541354-34546005 (+)
C3H/HeJ	MGP_C3HHeJ_G0026888	protein coding gene	Chr3:35491889-35496580 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027591	protein coding gene	Chr3:37142039-37146689 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024952	protein coding gene	Chr3:32474792-32479478 (+)
CAST/EiJ	MGP_CASTEiJ_G0026341	protein coding gene	Chr3:35387325-35392000 (+)
CBA/J	MGP_CBAJ_G0026865	protein coding gene	Chr3:38145113-38149804 (+)
DBA/2J	MGP_DBA2J_G0026999	protein coding gene	Chr3:34228085-34232749 (+)
FVB/NJ	MGP_FVBNJ_G0026967	protein coding gene	Chr3:33670234-33674885 (+)
LP/J	MGP_LPJ_G0027111	protein coding gene	Chr3:36290763-36295460 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026986	protein coding gene	Chr3:40633462-40638135 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027650	protein coding gene	Chr3:35293733-35298406 (+)
PWK/PhJ	MGP_PWKPhJ_G0026074	protein coding gene	Chr3:33919347-33924162 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025886	protein coding gene	Chr3:34659216-34663895 (+)
WSB/EiJ	MGP_WSBEiJ_G0026415	protein coding gene	Chr3:35311833-35316524 (+)

Human Ortholog

SPRY1, sprouty RTK signaling antagonist 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPRY1, sprouty RTK signaling antagonist 1
Synonyms

hSPRY1
Links

HGNC:11269

NCBI Gene ID: 10252

neXtProt AC: NX_O43609

UniProt: O43609
Chr Location

4q28.1; chr4:123396795-123403760 (+) GRCh38

MGI Vertebrate Homology

Spry1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SPRY1
Gene Tree

Spry1

less

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

less

Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotypes from multigenic genotypes
64 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

3
Radiation induced

2
Targeted

9
Genomic Mutations

2 involving Spry1
Incidental Mutations

APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display postnatal lethality, premature death, abnormal kidney morphology and development with multiple ectopic ureteric buds, multiple ureters, and hydroureter.

less

All GO Annotations

49
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

988
Tissues

169
cDNA Data

38
Literature Summary

139

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase spry1

ZFIN spry1

less

All Sequences

47
RefSeq

8
UniProt

4
CCDS

CCDS17322.1

Ensembl

ENSMUSG00000037211 (Evidence)
NCBI Gene

24063

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037211	Ensembl Gene Model \| MGI Sequence Detail	4652	C57BL/6J	± kb
transcript	ENSMUST00000038569	Ensembl \| MGI Sequence Detail	2481	Not Applicable
polypeptide	ENSMUSP00000049292	Ensembl \| MGI Sequence Detail	313	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000015582 protein sprouty homolog 1

(term hierarchy)
InterPro Domains

IPR007875 Sprouty

IPR051192 Sprouty domain-containing protein

less

All nucleic 58

cDNA 40

Primer pair 7

Other 11

Microarray probesets 2

Summaries

All 221

Developmental Gene Expression 139

Diseases 2

Gene Ontology 15

Phenotypes 64
Earliest

J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
Latest

J:353452 Altes G, et al., Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice. Sci Rep. 2024 Aug 22;14(1):19479

TSS for Spry1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28908	Chr3:37693813-37693842 (+)	-268 bp
Tssr28909	Chr3:37694054-37694061 (+)	-38 bp
Tssr28910	Chr3:37694077-37694092 (+)	-11 bp
Tssr28911	Chr3:37694094-37694113 (+)	8 bp
Tssr28912	Chr3:37694134-37694135 (+)	39 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24