Aloxe3 MGI Mouse Gene Detail - MGI:1345140 - arachidonate lipoxygenase 3

Symbol

Aloxe3
Name

arachidonate lipoxygenase 3
Synonyms

e-LOX-3

Feature Type

protein coding gene
IDs

MGI:1345140
NCBI Gene: 23801
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:69016722-69039941 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.38 cM
Mapping Data

3 experiments

SNPs within 2kb

608 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1345140	protein coding gene	Chr11:69016243-69039941 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018521	protein coding gene	Chr11:69531184-69554480 (+)
A/J	MGP_AJ_G0018490	protein coding gene	Chr11:66917304-66941122 (+)
AKR/J	MGP_AKRJ_G0018459	protein coding gene	Chr11:68920807-68944024 (+)
BALB/cJ	MGP_BALBcJ_G0018461	protein coding gene	Chr11:67238877-67262256 (+)
C3H/HeJ	MGP_C3HHeJ_G0018274	protein coding gene	Chr11:68937452-68962266 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018913	protein coding gene	Chr11:71644982-71669261 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016557	protein coding gene	Chr11:63856780-63880787 (+)
CAST/EiJ	MGP_CASTEiJ_G0017830	protein coding gene	Chr11:69174734-69199322 (+)
CBA/J	MGP_CBAJ_G0018248	protein coding gene	Chr11:74855733-74882386 (+)
DBA/2J	MGP_DBA2J_G0018357	protein coding gene	Chr11:66516035-66540252 (+)
FVB/NJ	MGP_FVBNJ_G0018347	protein coding gene	Chr11:66138065-66161968 (+)
LP/J	MGP_LPJ_G0018428	protein coding gene	Chr11:70118171-70141471 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018370	protein coding gene	Chr11:75480156-75505682 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018954	protein coding gene	Chr11:69166120-69191295 (+)
PWK/PhJ	MGP_PWKPhJ_G0017605	protein coding gene	Chr11:67153280-67177331 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017393	protein coding gene	Chr11:68998933-69025078 (+)
WSB/EiJ	MGP_WSBEiJ_G0017883	protein coding gene	Chr11:68806895-68831349 (+)

Human Ortholog

ALOXE3, arachidonate epidermal lipoxygenase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ALOXE3, arachidonate epidermal lipoxygenase 3
Synonyms

ARCI3, E-LOX, eLOX-3, eLOX3, LI5
Links

HGNC:13743

NCBI Gene ID: 59344

neXtProt AC: NX_Q9BYJ1

UniProt: Q9BYJ1
Chr Location

17p13.1; chr17:8095900-8119047 (-) GRCh38

MGI Vertebrate Homology

Aloxe3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ALOXE3
Gene Tree

Aloxe3

Diseases

2 with human ALOXE3 associations

				Human Disease	Mouse Models
				autosomal recessive congenital ichthyosis 1 IDs autosomal recessive congenital ichthyosis 1 DOID:0060656 ICD10CM:Q80.2 OMIM:242300 ORDO:100976 ORDO:281122 ORDO:313
				autosomal recessive congenital ichthyosis 3 IDs autosomal recessive congenital ichthyosis 3 DOID:0060711 ICD10CM:Q80.2 OMIM:606545

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

18 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Targeted

6
Genomic Mutations

1 involving Aloxe3
Incidental Mutations

APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit complete neonatal lethality, imapired skin barrier function, dehydration, tightly packed stratum corneum, impaired stratum corneum desquamation and reduced levels of ester-bound ceramide in the epidermis.

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All GO Annotations

44
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

3
cDNA Data

9
Literature Summary

6

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase aloxe3

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All Sequences

48
RefSeq

12
UniProt

3
CCDS

CCDS24884.1

Ensembl

ENSMUSG00000020892 (Evidence)
NCBI Gene

23801

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020892	Ensembl Gene Model \| MGI Sequence Detail	23220	C57BL/6J	± kb
transcript	ENSMUST00000021268	Ensembl \| MGI Sequence Detail	3019	Not Applicable
polypeptide	ENSMUSP00000021268	Ensembl \| MGI Sequence Detail	711	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003963 hydroperoxide isomerase ALOXE3

(term hierarchy)
EC

4.2.1.152, 5.4.4.7
InterPro Domains

IPR036226 Lipoxigenase, C-terminal domain superfamily

IPR000907 Lipoxygenase

IPR020834 Lipoxygenase, conserved site

IPR013819 Lipoxygenase, C-terminal

IPR020833 Lipoxygenase, iron binding site

IPR001885 Lipoxygenase, mammalian

IPR042062 Lipoxygenase, vertebrates, PLAT domain

IPR001024 PLAT/LH2 domain

IPR036392 PLAT/LH2 domain superfamily

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All nucleic 13

cDNA 10

Primer pair 3

Microarray probesets 3

Summaries

All 49

Developmental Gene Expression 6

Gene Ontology 12

Phenotypes 11
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Aloxe3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102414	Chr11:69016930-69016942 (+)	214 bp
Tssr102415	Chr11:69017012-69017036 (+)	302 bp
Tssr102416	Chr11:69017044-69017075 (+)	338 bp
Tssr102417	Chr11:69024961-69024990 (+)	8,254 bp
Tssr102418	Chr11:69033388-69033392 (+)	16,668 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24