Ik MGI Mouse Gene Detail - MGI:1345142

Symbol

Ik
Name

IK cytokine
Synonyms

MuRED

Feature Type

protein coding gene
IDs

MGI:1345142
NCBI Gene: 24010
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr18:36877731-36890688 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 19.46 cM, cytoband B3
Mapping Data

2 experiments

SNPs within 2kb

375 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1345142	protein coding gene	Chr18:36877709-36890692 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024288	protein coding gene	Chr18:35157664-35170690 (+)
A/J	MGP_AJ_G0024254	protein coding gene	Chr18:33918692-33931680 (+)
AKR/J	MGP_AKRJ_G0024222	protein coding gene	Chr18:34873739-34886729 (+)
BALB/cJ	MGP_BALBcJ_G0024254	protein coding gene	Chr18:33967826-33980823 (+)
C3H/HeJ	MGP_C3HHeJ_G0024021	protein coding gene	Chr18:34937672-34950651 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024695	protein coding gene	Chr18:36393268-36407338 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022135	protein coding gene	Chr18:34011126-34024883 (+)
CAST/EiJ	MGP_CASTEiJ_G0023496	protein coding gene	Chr18:34952500-34965507 (+)
CBA/J	MGP_CBAJ_G0023989	protein coding gene	Chr18:37471946-37484939 (+)
DBA/2J	MGP_DBA2J_G0024121	protein coding gene	Chr18:33535770-33548805 (+)
FVB/NJ	MGP_FVBNJ_G0024088	protein coding gene	Chr18:33245457-33258455 (+)
LP/J	MGP_LPJ_G0024203	protein coding gene	Chr18:35191929-35204903 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024116	protein coding gene	Chr18:38685036-38699027 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024744	protein coding gene	Chr18:34743413-34757123 (+)
PWK/PhJ	MGP_PWKPhJ_G0023240	protein coding gene	Chr18:33796638-33810013 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023047	protein coding gene	Chr18:34996512-35009569 (+)
WSB/EiJ	MGP_WSBEiJ_G0023559	protein coding gene	Chr18:34663848-34676841 (+)

Human Ortholog

IK, IK cytokine

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IK, IK cytokine
Synonyms

CSA2, RED, RER
Links

HGNC:5958

NCBI Gene ID: 3550

neXtProt AC: NX_Q13123

UniProt: Q13123
Chr Location

5q31.3; chr5:140647058-140662480 (+) GRCh38

MGI Vertebrate Homology

Ik stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IK
Gene Tree

Ik

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

3
Gene trapped

8
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

23
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

191
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN ik

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All Sequences

58
RefSeq

2
UniProt

6
CCDS

CCDS57119.1

Ensembl

ENSMUSG00000024474 (Evidence)
NCBI Gene

24010

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024474	Ensembl Gene Model \| MGI Sequence Detail	12958	C57BL/6J	± kb
transcript	ENSMUST00000237095	Ensembl \| MGI Sequence Detail	466	Not Applicable
polypeptide	ENSMUSP00000158258	Ensembl \| MGI Sequence Detail	133	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000008976 protein Red

(term hierarchy)
InterPro Domains

IPR012492 Protein RED, C-terminal

IPR039896 Protein Red-like

IPR012916 RED-like, N-terminal

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All nucleic 194

cDNA 193

Primer pair 1

Microarray probesets 5

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 8
Earliest

J:54439 Bouzinba-Segard H, et al., Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat. Gene. 1999 Apr 16;230(2):145-54
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ik:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150665	Chr18:36877726-36877790 (+)	27 bp
Tssr150666	Chr18:36882293-36882312 (+)	4,572 bp
Tssr150667	Chr18:36884153-36884166 (+)	6,429 bp
Tssr150668	Chr18:36884215-36884235 (+)	6,494 bp
Tssr150669	Chr18:36886486-36886508 (+)	8,766 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24