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Grk1 Gene Detail
Summary
  • Symbol
    Grk1
  • Name
    G protein-coupled receptor kinase 1
  • Synonyms
    Rhok, RK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345146
    NCBI Gene: 24013
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:13455081-13471951 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 5.93 cM, cytoband A2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    616 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345146
 protein coding gene Chr8:13455081-13471951 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033380
 protein coding gene Chr8:10756541-10773259 (+)
A/J MGP_AJ_G0033360
 protein coding gene Chr8:10366454-10383033 (+)
AKR/J MGP_AKRJ_G0033291
 protein coding gene Chr8:10649211-10667339 (+)
BALB/cJ MGP_BALBcJ_G0033361
 protein coding gene Chr8:10495655-10512306 (+)
C3H/HeJ MGP_C3HHeJ_G0033074
 protein coding gene Chr8:10860399-10877735 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033873
 protein coding gene Chr8:11128601-11146586 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030841
 protein coding gene Chr8:9862298-9878759 (+)
CAST/EiJ MGP_CASTEiJ_G0032396
 protein coding gene Chr8:10618435-10634868 (+)
CBA/J MGP_CBAJ_G0033047
 protein coding gene Chr8:11603688-11622120 (+)
DBA/2J MGP_DBA2J_G0033200
 protein coding gene Chr8:10311497-10328175 (+)
FVB/NJ MGP_FVBNJ_G0033149
 protein coding gene Chr8:10325404-10342452 (+)
LP/J MGP_LPJ_G0033294
 protein coding gene Chr8:10670523-10689167 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033183
 protein coding gene Chr8:11819937-11840066 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033890
 protein coding gene Chr8:10706399-10724978 (+)
PWK/PhJ MGP_PWKPhJ_G0032109
 protein coding gene Chr8:10365682-10383009 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031951
 protein coding gene Chr8:10599445-10615946 (+)
WSB/EiJ MGP_WSBEiJ_G0032512
 protein coding gene Chr8:10741482-10760209 (+)



Homology
more
  • Human Ortholog
    GRK1, G protein-coupled receptor kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRK1, G protein-coupled receptor kinase 1
  • Synonyms
    GPRK1, RHOK, RK
  • Links
    NCBI Gene ID: 6011
    neXtProt AC: NX_Q15835
    UniProt: Q15835

  • Chr Location
    13q34; chr13:113648199-113737736 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Grk1 mouse models; 2 with human GRK1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Analysis of homozygous null mice revealed abnormal photoresponses and light-induced apoptosis in rods. Mutant mice may serve as models of Oguchi disease and retinal degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    2
  • cDNA Data
    32
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24013 NCBI Gene Model | MGI Sequence Detail 16871 C57BL/6J ±  kb
    transcript NM_011881 RefSeq | MGI Sequence Detail 7462 Not Specified  
    polypeptide Q9WVL4 UniProt | EBI | MGI Sequence Detail 564 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 2
      cDNA 33

      Microarray probesets 2
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 9
      Phenotypes 29
    • Earliest
      J:54021 Chen CK, et al., Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3718-22
    • Latest
      J:334815 Ng L, et al., Biphasic expression of thyroid hormone receptor TRbeta1 in mammalian retina and anterior ocular tissues. Front Endocrinol (Lausanne). 2023;14:1174600
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory