Septin3 MGI Mouse Gene Detail - MGI:1345148

Symbol

Septin3
Name

septin 3
Synonyms

3110018K01Rik, B530002E20Rik, Gm46500, Sep3, Sept3

Feature Type

protein coding gene
IDs

MGI:1345148
NCBI Gene: 24050
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr15:82153003-82178775 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 38.56 cM, cytoband E2
Mapping Data

5 experiments

SNPs within 2kb

706 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1345148	protein coding gene	Chr15:82153003-82178775 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022140	protein coding gene	Chr15:82783544-82804715 (+)
A/J	MGP_AJ_G0022100	protein coding gene	Chr15:79846669-79866117 (+)
AKR/J	MGP_AKRJ_G0022076	protein coding gene	Chr15:82067963-82087469 (+)
BALB/cJ	MGP_BALBcJ_G0022106	protein coding gene	Chr15:79896453-79915974 (+)
C3H/HeJ	MGP_C3HHeJ_G0021877	protein coding gene	Chr15:82076768-82096276 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022549	protein coding gene	Chr15:86022620-86042376 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020078	protein coding gene	Chr15:76283997-76303619 (+)
CAST/EiJ	MGP_CASTEiJ_G0021397	protein coding gene	Chr15:82872739-82893658 (+)
CBA/J	MGP_CBAJ_G0021842	protein coding gene	Chr15:88723204-88742704 (+)
DBA/2J	MGP_DBA2J_G0021970	protein coding gene	Chr15:79316908-79336437 (+)
FVB/NJ	MGP_FVBNJ_G0021947	protein coding gene	Chr15:78386270-78405769 (+)
LP/J	MGP_LPJ_G0022039	protein coding gene	Chr15:82933918-82953419 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021968	protein coding gene	Chr15:93614647-93635275 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022563	protein coding gene	Chr15:82174082-82194864 (+)
PWK/PhJ	MGP_PWKPhJ_G0021139	protein coding gene	Chr15:79374427-79394565 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020978	protein coding gene	Chr15:81954744-81976384 (+)
WSB/EiJ	MGP_WSBEiJ_G0021448	protein coding gene	Chr15:82596290-82615804 (+)

Human Ortholog

SEPTIN3, septin 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SEPTIN3, septin 3
Synonyms

bK250D10.3, SEP3, SEPT3
Links

HGNC:10750

NCBI Gene ID: 55964

neXtProt AC: NX_Q9UH03

UniProt: Q9UH03
Chr Location

22q13.2; chr22:41969443-41998221 (+) GRCh38

MGI Vertebrate Homology

Septin3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SEPTIN3
Protein SuperFamily

Septin
Gene Tree

Septin3

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 4 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

2
Targeted

5
Genomic Mutations

3 involving Septin3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit a normal phenotype.

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All GO Annotations

22
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

903
Tissues

89
cDNA Data

97
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase septin3

ZFIN septin3

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All Sequences

88
RefSeq

30
UniProt

7
CCDS

CCDS37157.1, CCDS88812.1, CCDS88813.1, CCDS88814.1

Ensembl

ENSMUSG00000022456 (Evidence)
NCBI Gene

24050

			Length	Strain/Species	Flank
genomic	24050	NCBI Gene Model \| MGI Sequence Detail	25773	C57BL/6J	± kb
transcript	NM_001368784	RefSeq \| MGI Sequence Detail	6443	C57BL/6
polypeptide	Q9Z1S5	UniProt \| EBI \| MGI Sequence Detail	350	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000014655 neuronal-specific septin-3

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR016491 Septin

IPR008114 Septin 3

IPR030379 Septin-type guanine nucleotide-binding (G) domain
GlyGen

Q9Z1S5 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 99

cDNA 97

Primer pair 1

Other 1

Microarray probesets 6

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MGI:1925606, MGI:2146169, MGI:2442742, MGI:5826137, MGI:6368832

Summaries

All 63

Developmental Gene Expression 7

Diseases 1

Gene Ontology 6

Phenotypes 31
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Septin3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132370	Chr15:82152994-82153021 (+)	5 bp
Tssr132371	Chr15:82159180-82159235 (+)	6,205 bp
Tssr132372	Chr15:82159251-82159270 (+)	6,258 bp
Tssr132373	Chr15:82159398-82159482 (+)	6,437 bp
Tssr4667	Chr15:82167340-82167351 (+)	14,343 bp
Tssr132374	Chr15:82176874-82176877 (+)	23,873 bp
Tssr132375	Chr15:82176987-82177013 (+)	23,997 bp
Tssr132376	Chr15:82177015-82177030 (+)	24,020 bp
Tssr132377	Chr15:82178137-82178176 (+)	25,154 bp
Tssr132378	Chr15:82178291-82178308 (+)	25,297 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24