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Scn11a Gene Detail
Summary
  • Symbol
    Scn11a
  • Name
    sodium channel, voltage-gated, type XI, alpha
  • Synonyms
    NaN, NaT, NSS2, SNS2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345149
    NCBI Gene: 24046
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr9:119582829-119654522 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 71.33 cM, cytoband F3-F4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2143 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345149
 protein coding gene Chr9:119582825-119654522 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035423
 protein coding gene Chr9:122552020-122628895 (-)
A/J MGP_AJ_G0035404
 protein coding gene Chr9:117980047-118051722 (-)
AKR/J MGP_AKRJ_G0035337
 protein coding gene Chr9:121059623-121140104 (-)
BALB/cJ MGP_BALBcJ_G0035400
 protein coding gene Chr9:117859191-117940074 (-)
C3H/HeJ MGP_C3HHeJ_G0035108
 protein coding gene Chr9:121525581-121603751 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035923
 protein coding gene Chr9:125902401-125980869 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032805
 protein coding gene Chr9:115180593-115253379 (-)
CAST/EiJ MGP_CASTEiJ_G0034412
 protein coding gene Chr9:121534058-121615254 (-)
CBA/J MGP_CBAJ_G0035075
 protein coding gene Chr9:130621975-130701117 (-)
DBA/2J MGP_DBA2J_G0035234
 protein coding gene Chr9:117421047-117493871 (-)
FVB/NJ MGP_FVBNJ_G0035181
 protein coding gene Chr9:116293609-116366710 (-)
LP/J MGP_LPJ_G0035313
 protein coding gene Chr9:122893668-122971425 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035222
 protein coding gene Chr9:131568532-131650197 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035942
 protein coding gene Chr9:121446432-121521447 (-)
PWK/PhJ MGP_PWKPhJ_G0034117
 protein coding gene Chr9:117860695-117935380 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033953
 protein coding gene Chr9:121545525-121619689 (-)
WSB/EiJ MGP_WSBEiJ_G0034532
 protein coding gene Chr9:121336644-121418013 (-)



Homology
more
  • Human Ortholog
    SCN11A, sodium voltage-gated channel alpha subunit 11
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCN11A, sodium voltage-gated channel alpha subunit 11
  • Synonyms
    FEPS3, HSAN7, NaN, NAV1.9, PN5, SCN12A, SNS-2
  • Links
    NCBI Gene ID: 11280
    neXtProt AC: NX_Q9UI33
    UniProt: Q9UI33

  • Chr Location
    3p22.2; chr3:38845764-39052157 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Scn11a mouse models; 2 with human SCN11A associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 10 alleles in 8 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous and heterozygous for one null allele display decreased duration of inflammation induced thermal hyperalgesia and decreased late phase pain responses to inflammatory stimuli. Mice homozygous for a second allele appear normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    93
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    870
  • Tissues
    70
  • cDNA Data
    8
  • Literature Summary
    15
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 24046 NCBI Gene Model | MGI Sequence Detail 71694 C57BL/6J ±  kb
transcript NM_011887 RefSeq | MGI Sequence Detail 5837 Not Specified  
polypeptide Q9R053 UniProt | EBI | MGI Sequence Detail 1765 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000002097 sodium channel protein type 11 subunit alpha
    (term hierarchy)
  • InterPro Domains
    IPR005821 Ion transport domain
    IPR010526 Sodium ion transport-associated domain
    IPR027359 Voltage-dependent channel domain superfamily
    IPR043203 Voltage-gated cation channel calcium and sodium
    IPR001696 Voltage gated sodium channel, alpha subunit
    IPR044564 Voltage-gated sodium channel alpha subunit, inactivation gate
  • GlyGen
    Q9R053 11 sites
Molecular
Reagents
less
  • All nucleic 16
    cDNA 8
    Primer pair 6
    Other 2

    Microarray probesets 2
References
more
  • Summaries
    All 74
    Developmental Gene Expression 15
    Diseases 2
    Gene Ontology 24
    Phenotypes 35
  • Earliest
    J:57019 Dib-Hajj SD, et al., Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN. Genomics. 1999 Aug 1;59(3):309-18
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory