Slc29a2 MGI Mouse Gene Detail - MGI:1345278 - solute carrier family 29 (nucleoside transporters), member 2

Symbol

Slc29a2
Name

solute carrier family 29 (nucleoside transporters), member 2
Synonyms

Der12, ENT2, HNP36

Feature Type

protein coding gene
IDs

MGI:1345278
NCBI Gene: 13340
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr19:5073888-5082000 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.23 cM, cytoband A
Mapping Data

2 experiments

SNPs within 2kb

289 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1345278	protein coding gene	Chr19:5069085-5082000 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024685	protein coding gene	Chr19:1950197-1958156 (+)
A/J	MGP_AJ_G0024651	protein coding gene	Chr19:1842765-1850736 (+)
AKR/J	MGP_AKRJ_G0024624	protein coding gene	Chr19:1897805-1905758 (+)
BALB/cJ	MGP_BALBcJ_G0024651	protein coding gene	Chr19:1838988-1846957 (+)
C3H/HeJ	MGP_C3HHeJ_G0024419	protein coding gene	Chr19:1900158-1908125 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025098	protein coding gene	Chr19:2007126-2015085 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022528	protein coding gene	Chr19:1777665-1785818 (+)
CAST/EiJ	MGP_CASTEiJ_G0023891	protein coding gene	Chr19:1925930-1933886 (+)
CBA/J	MGP_CBAJ_G0024390	protein coding gene	Chr19:2087889-2095928 (+)
DBA/2J	MGP_DBA2J_G0024518	protein coding gene	Chr19:1833079-1841044 (+)
FVB/NJ	MGP_FVBNJ_G0024485	protein coding gene	Chr19:1833967-1841913 (+)
LP/J	MGP_LPJ_G0024604	protein coding gene	Chr19:1942316-1950279 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024515	protein coding gene	Chr19:1970004-1977975 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025146	protein coding gene	Chr19:1900465-1908428 (+)
PWK/PhJ	MGP_PWKPhJ_G0023637	protein coding gene	Chr19:1868973-1877217 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023442	protein coding gene	Chr19:1883168-1894557 (+)
WSB/EiJ	MGP_WSBEiJ_G0023953	protein coding gene	Chr19:1903809-1911753 (+)

Human Ortholog

SLC29A2, solute carrier family 29 member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC29A2, solute carrier family 29 member 2
Synonyms

DER12, ENT2, hENT2, HNP36
Links

HGNC:11004

NCBI Gene ID: 3177

neXtProt AC: NX_Q14542

UniProt: Q14542
Chr Location

11q13.2; chr11:66362521-66372446 (-) GRCh38

MGI Vertebrate Homology

Slc29a2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC29A2
Protein SuperFamily

ENT
Gene Tree

Slc29a2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Gene trapped

3
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available

Mice homozygous for a gene trap allele exhibit normal adenosine uptake in erythrocytes and protection from acute lung injury.

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All GO Annotations

81
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

28
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc29a2

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All Sequences

60
RefSeq

7
UniProt

4
CCDS

CCDS50354.1

Ensembl

ENSMUSG00000024891 (Evidence)
NCBI Gene

13340

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024891	Ensembl Gene Model \| MGI Sequence Detail	8113	C57BL/6J	± kb
transcript	ENSMUST00000236152	Ensembl \| MGI Sequence Detail	2619	Not Applicable
polypeptide	ENSMUSP00000157780	Ensembl \| MGI Sequence Detail	456	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015055 equilibrative nucleoside transporter 2

(term hierarchy)
InterPro Domains

IPR002259 Equilibrative nucleoside transporter

IPR036259 MFS transporter superfamily

IPR034764 Nucleoside transporter ENT1/ENT2
GlyGen

Q61672 1 site

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All nucleic 31

cDNA 30

Primer pair 1

Microarray probesets 3

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MGD-MRK-24063, MGI:103195

Summaries

All 49

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 10
Earliest

J:27223 Lanahan A, et al., Growth factor-induced delayed early response genes. Mol Cell Biol. 1992 Sep;12(9):3919-29
Latest

J:342585 Ruan W, et al., Targeting myocardial equilibrative nucleoside transporter ENT1 provides cardioprotection by enhancing myeloid Adora2b signaling. JCI Insight. 2023 Jun 8;8(11)

TSS for Slc29a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154374	Chr19:5074070-5074183 (+)	239 bp
Tssr154375	Chr19:5074190-5074210 (+)	312 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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